>

What is Clotrimazole Akrihin ointment for? Clotrimazole Acri: instructions for the use of ointments and tablets

R N001917 / 02

Trade name of the drug:

Clotrimazole-Akrikhin

International non-proprietary name:

clotrimazole

Dosage form:

ointment for external use

Composition

100 g of ointment contain:
active substance: clotrimazole in terms of 100% substance -1 g;
excipients: propylene glycol - 12.5 g, methyl parahydroxybenzoate (nipagin) - 0.2 g, succinic acid - 0.5 g, sodium benzoate - 6 g, emulsion wax - 3 g, castor oil - 14 g, methyl cellulose - 3 g, distilled monoglycerides -1.5 g, purified water - up to 100 g.

Description

The ointment is white or almost white in color with a weak specific odor.

Pharmacotherapeutic group:

antifungal agent

ATX code:

D01AC01

Pharmacological properties

Pharmacodynamics.
An antifungal agent from the group of imidazole derivatives for external use, reduces the synthesis of ergosterol, which is an integral part of the cell membrane of the microbial wall, and leads to a change in its structure and properties.

In small concentrations it acts fungistatically, and in large concentrations (more than 20 μg / ml) it is fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

It is active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and mold fungi (Candida spp., Torulopsis glabrata, Rhodotorula spp., Pityrosporum orbiculare).

Pharmacokinetics.
It is poorly absorbed through the skin and mucous membranes and practically does not have a systemic effect. It accumulates in the stratum corneum of the epidermis, penetrates into the keratin of the nails. The concentration in the deep layers of the epidermis is higher than the minimum inhibitory concentration for dermatophytes.

Indications for use:

  • fungal diseases of the skin, including skin folds and feet, caused by dermatophytes, yeast (Candida spp.), molds and other fungi and pathogens sensitive to clotrimazole: dermatomycosis, dermatophytosis, trichophytosis, epidermophytosis, microsporia, fungal candidiasis, interpalium paronychia;
  • mycoses complicated by secondary pyoderma, as part of complex therapy;
  • pityriasis versicolor, versicolor versicolor, erythrasma.

    • Contraindications:

    Hypersensitivity to potrimazole or excipients, pregnancy (I trimester), children under 2 years of age.

    Carefully

    Lactation period, pregnancy (II and III trimester).

    Method of administration and dosage

    Outwardly. Adults, in the absence of other appointments, are recommended to apply the ointment 2-3 times a day in a thin layer on previously cleaned and dry affected skin areas. A single dose on a palm-sized surface area - a column of ointment 5 mm long. Regular application of the ointment is essential for successful treatment.

    The duration of therapy is individual and depends on the severity and localization of the disease. To achieve full recovery, you should not stop treatment with the ointment immediately after the disappearance of acute symptoms of inflammation or subjective complaints.

    The duration of therapy should be about 4 weeks on average.

    Pityriasis versicolor heals mainly within 1-3 weeks, and erythrasma within 2-4 weeks.

    In children from 2 years of age, the drug is used in the doses indicated above.

    Side effects

    Local reactions: burning, swelling, irritation and peeling of the skin, paresthesia, erythematous rash, blistering.
    Allergic reactions: itching, urticaria.

    Overdose

    Low systemic absorption of the active ingredient of the drug when applied externally makes an overdose almost impossible.

    Interaction with other medicinal products

    Amphotericin B, nystatin, natamycin reduce the effectiveness of clotrimazole when used simultaneously.

    special instructions

    Avoid contact with the mucous membrane of the eyes.
    In patients with hepatic insufficiency, the functional state of the liver should be monitored periodically.
    If signs of hypersensitivity or irritation appear, treatment is discontinued.
    If there is no effect within 4 weeks, the diagnosis should be confirmed.
    In children, large surfaces should be avoided.

    Release form:

    Ointment for external use 1%.
    20 g in an aluminum tube. Each tube, together with instructions for use, is placed in a cardboard box.

    Storage conditions

    In a dry, dark place, at a temperature not exceeding 15 ° C.
    Keep out of the reach of children.

    Shelf life

    2 years. Do not use after the expiration date.

    Pharmacy dispensing:

    Without recipe.

    Manufacturer / Organization accepting customer claims:

    Open Joint Stock Company "Chemical and Pharmaceutical Plant" AKRIKHIN "(JSC" AKRIKHIN "), Russia
    142450, Moscow region, Noginsky district, Old Kupavna, st. Kirov, 29.

    Akrikhin Clotrimazole belongs to a group of drugs intended for the treatment of fungal diseases from the imidazole group. The product is a white crystalline mass without any odors. Clotrimazole is practically impossible to dissolve in water and is rather difficult to dissolve in ethers.

    The drug is available in the following medical forms:

    1. Ointment. 100 mg of the drug accounts for 1 g of the active ingredient - Clotrimazole. As auxiliary substances are sodium benzoate, purified water, propylene glycol, succinic acid and other components.
    2. Vaginal tablets. Contains 1% of the active ingredient with the addition of lactose, cellulose, citric acid, potato starch and other components.
    3. Cream. In addition to the active ingredient, synthetic spermaceti, benzyl and cetostearyl alcohol, sorbitan stearate, octyldodecanol and purified water are added to the composition.

    The drug is also available in the form of a gel and a solution with a similar composition.

    Pharmacodynamics

    Pharmacological action has a wide range of applications. The active substance of Clotrimazole Akrikhin, a derivative of imidazole, disrupts the synthesis of ergosterol, which is found in the membranes of the fungus, with the subsequent destruction of its cells.

    In large doses, the drug acts fungicidal, that is, it has a toxic effect on the "nature" of the fungus, thereby destroying it.

    Proven to be effective against yeast-like fungi, dermatophytes, molds and versicolor.

    It has a fatal effect on erythrasma pathogens. Perfectly copes with gram-positive pathogens like streptococci and staphylococci. Copes well with gram-negative bacteria.

    Pharmacokinetics

    The drug is rapidly metabolized. In the case of intravaginal administration of the drug, absorption occurs at the level of 3-10% of the dose received by the body. Both high doses administered vaginally and low doses that enter the blood retain their concentration for no more than 72 hours. Clotrimazole is excreted in urine and faeces.

    The basis of the action of Clotrimazole is the ability to block the synthesis of proteins and nucleic acids, which do not allow fungal formations to build their cellular structure. If the cell membrane of the fungal formations is damaged, then they begin to die quickly.

    Indications for the use of various forms of clotrimazole

    The drug of any form of release is primarily intended for the destruction of genital infections. Clotrimazole therapy can be carried out with the debridement of the birth canal prior to childbirth.

    Akrikhin ointment and cream help in getting rid of fungal nail diseases such as fungal paronychia or onychomycosis. Allows you to improve the condition in the presence of fungal erosions, candidiasis, complications of secondary pyoderma mycoses and simple diaper rash.

    Gel, ointment and cream are used to eliminate lichen and erythrasma. Contribute to getting rid of yeast and molds of the skin.

    You cannot get rid of pink lichen with Clotrimazole. The drug is not suitable for the treatment of fungal diseases of an infectious or viral origin. The drug will not help with diseases caused by nervous shocks and stressful situations.

    In gynecology, the agent used is most often ointment, vaginal tablets or clotrimazole suppositories. Allows you to get rid of thrush. The drug is an excellent remedy for the recurrence of infectious diseases in the genital area.

    Before the delivery process, Clotrimazole is used as a sanitation agent. Doctors use a solution, ointment, and cream.

    Suppositories or suspensions are used to treat genital superinfections and candidiasis. The drug can be prescribed at the beginning of sexual activity to prevent the possible occurrence of genital diseases.

    The tablet form of Clotrimazole is prescribed in the presence of infections of the vagina and vulva.

    Contraindications

    In most cases, Clotrimazole is well tolerated by all patients, especially since it is used topically. It is not recommended to use the drug if the patient has an individual intolerance to the active substance.

    Method of administration and dosage

    The cream is used exclusively for topical use in the presence of thrush or other fungal diseases. The product is applied to the affected areas several times with light massage movements.

    In the presence of fungal infections in one partner, the cream must be used by both.

    The duration of the course of treatment depends entirely on the identified disease. With vulvitis or balanitis, it is about 1.5 weeks. In the treatment of dermatomycosis, the duration of therapy is about 1 month.

    For prophylaxis, Clotrimazole should be used for 4 weeks, the main thing is not to stop treatment.

    Applications are made from the Clotrimazole solution. Before the procedure, the skin on which the product will be applied must be thoroughly washed with soapy water and dried well. It is necessary to process the affected surface at least 3 times a day.

    When using a solution to combat fungal disease of the feet, they are treated after each wash. The greatest efficiency of the solution has been proven in the presence of onychomycosis, since it is the solution that perfectly penetrates the tissue structures.

    The method of applying the gel is similar to that of the ointment. The peculiarity of the release form is that the gel is easier to apply to hard-to-reach places. Clotrimazole vaginal suppositories are most often used for thrush. The suspension is injected deep into the vagina every day, preferably at night, for 6 days.

    Side effects

    Despite rare negative reviews from patients, Clotrimazole can cause some discomfort in the form of burning and swelling of the skin and mucous membranes. Blisters and tingling sensations may develop, after which the skin may flake off.

    If you use any form of Clotrimazole for women in position, then the drug is recommended only after the 2nd trimester, with parallel control of analyzes. Use in the 2nd and 3rd trimester is not dangerous for the fetus, but you should be very careful with applications.

    Instructions for the use of any form of the drug do not recommend using it during lactation, since the possibility of clotrimazole penetration into breast milk has not been fully studied.

    Overdose

    If drugs are applied to the skin or injected intravaginally, then the possibility of intoxication is practically absent, since the drug enters the bloodstream at a minimum dosage. If the drug accidentally gets inside, then unpleasant symptoms such as nausea or diarrhea may appear.

    The best way to get rid of them is to cancel the drug and take sorbents.

    Interaction with other drugs

    special instructions

    It is necessary to ensure that the drug does not get into the eyes and inside the body. Do not use Clotrimazole if you have vaginal bleeding, lower abdominal pain, chills, or fever.

    Ointment "Clotrimazole-Acri" refers to antifungal and antimicrobial agents. It is widely used to treat gynecological, urological, dermatological diseases. The active ingredient in the product is active against various types of bacteria and fungi. The drug is produced in several forms, which is why it has a wide range of applications.

    Composition and form of release

    "Clotrimazole-Acri" is available in various dosage forms, namely:

    • white vaginal tablets;
    • antifungal ointment;
    • cream for external use;
    • vaginal cream;
    • solution.

    The composition of this product includes the substance clotrimazole, as well as other auxiliary components that facilitate the process of applying the product to the mucous membranes and skin.

    What is appointed for

    According to the instructions, "Clotrimazole-Acri" ointment destroys pathogenic cells. This remedy is especially effective against dermatophytes, mold and yeast-like fungi, as well as lichen. The ointment has an antimicrobial effect against various bacteria.

    According to the instructions, "Clotrimazole-Acri" is used in the presence of fungal diseases of the skin, mucous membranes and feet. It is a very effective remedy that takes effect almost immediately after application.

    To cleanse the birth canal and prevent infection, vaginal suppositories are used before surgery on the genitals.

    It is possible to independently diagnose the defeat of the integument by the fungus by the presence of non-inflamed scaly spots on the skin of pink, red, brown color, accompanied by severe itching. Stripes or specks of a white tint appear on the nail plates. Over time, the nail becomes thinner and begins to crumble. Candidal diaper rash is characterized by the presence of weeping areas on the skin surface with the appearance of a characteristic cheesy plaque.

    Application features

    According to the instructions for use, "Clotrimazole-Acri" in the form of a cream, solution or lotion is applied in a very thin layer to the skin and mucous membranes 2-3 times a day. The duration of therapy is approximately 4 weeks. After completing the course and eliminating the main symptoms of the disease, it is advisable to continue treatment for another 14 days.

    In case of fungal diseases, after obtaining the proper therapeutic effect, it is recommended to extend the therapy for another 2-3 weeks.

    A vaginal cream or gel is injected in small portions of 5 grams into the vagina once a day for 3 days. About the tablets "Clotrimazole-Acri" the instruction warns that they must be inserted deep into the vagina. The course of treatment depends on the dosage of the active ingredient. Additionally, you need to treat the external genitals with a cream, solution or ointment. If necessary, the course of therapy can be repeated.

    In the case of systematic use of the remedy, recovery occurs literally in a month from the beginning of treatment. Since the agent acts exclusively on growing and dividing microorganisms, its use should be continued for another 2 weeks after the elimination of the existing symptoms.

    Features of use in men and women

    As written in the instructions, Clotrimazole-Acri ointment has a strong effect on yeast fungi, slowing down their growth and stopping reproduction. This drug is prescribed for women with thrush and helps to eliminate:

    • burning;
    • redness in the genital area;
    • discharge.

    You can use the tool during complex therapy to achieve the best result. The drug can be used during pregnancy and breastfeeding. Before using the ointment, it is advisable to douch with herbal extracts of chamomile, oak bark or calendula.

    The body of a man is more resistant to yeast, so the symptoms of the pathological process are often absent. However, if thrush is diagnosed in a permanent sexual partner, then both must undergo treatment. Ointment "Clotrimazole-Acri" is applied to the head of the penis and foreskin.

    In the presence of fungal diseases, this remedy is applied externally in the prescribed dosages. Sex differences do not affect the course of therapy. The therapeutic regimen will be the same for men and women.

    With multi-colored lichen, the course of treatment is 5-7 days. With a foot fungus, it is continued until the symptoms are completely eliminated. With severe peeling of the skin at the site of the lesion, it is initially recommended to remove the stratum corneum. For this purpose, various ointments are used.

    Application for children

    According to the instructions, "Clotrimazole-Acri" can be used in the form of an ointment, gel or solution in the treatment of diseases in children. This remedy is applied to the place of diaper rash or the spread of the fungus. If the affected area is in the folds of the skin, the medicine is best used in the form of a solution. The ointment contains sage oil, which acts as an antiseptic and helps to eliminate severe itching and burning.

    The drug is applied at least 3 times a day for a month, including after the disappearance of the main signs of the disease. Treatment of diaper rash or fungal diseases in a child should be carried out under the strict supervision of a doctor to prevent relapse. It is important to remember that in the process of treating fungal diseases, the child's skin folds must be dry at all times.

    Side effects and contraindications

    "Clotrimazole-Acri" has practically no contraindications. This remedy is prohibited for use with hypersensitivity to individual components, as well as in the first trimester of pregnancy. In 2-3 trimesters and during breastfeeding, the drug is used with extreme caution and according to the testimony of a doctor.

    This remedy can provoke various side effects, in particular:

    • with vaginal administration: itching, burning, mucosal edema, vaginal discharge;
    • for external use: swelling, burning, peeling of the skin, rashes;
    • allergic reactions.

    To prevent re-infection with a urogenital infection, treatment is recommended for both partners and at the same time. With trichomoniasis, together with the ointment, you need to take other drugs with a systemic effect.

    Analogues of the drug, reviews, price

    The price of "Clotrimazole-Acri" in the form of an ointment is 75 rubles, and the cost of vaginal tablets is 32 rubles. Since this tool is not suitable for everyone, there are analogues that have the same principle of action. Among them are:

    1. "Canison".
    2. "Candide".
    3. "Imidil".
    4. "Amiclone".
    5. "Kanesten".

    Only a doctor should prescribe a drug. Reviews of "Clotrimazole-Acri" are only positive. According to consumers, this is a fairly effective tool that helps to quickly get rid of the manifestations of fungal diseases.

    R N000682 / 01

    Trade name of the drug:

    Clotrimazole-Akrikhin

    International Non-Proprietary Name (INN):

    clotrimazole

    Dosage form:

    vaginal pills

    Composition.

    1 vaginal tablet contains:
    active substance: clotrimazole 100 mg,
    excipients: milk sugar (lactose), potato starch, microcrystalline cellulose, citric acid, magnesium stearate.

    Description.

    The tablets are white or almost white in color, oval, biconvex.

    Pharmacotherapeutic group:

    antifungal agent.

    ATX code:

    pharmachologic effect

    Clotrimazole-Akrikhin is a broad-spectrum antifungal agent for topical use. The antimycotic effect of the active active ingredient clotrimazole (an imidazole derivative) is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the membrane permeability and causes subsequent cell lysis. In small concentrations it acts fungistatically, and in large concentrations it is fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

    Effective against dermatophytes, yeast-like and mold fungi, as well as the causative agent of pityriasis versicolor (Malazessia furfur) and the causative agent of erythrasma. It has an antimicrobial effect against gram-positive (staphylococci, streptococci) and gram-negative bacteria (Bacteroides, Cardnerella vaginalis), as well as against Trichomonas vaginalis.

    Pharmacokinetics
    When using Clotrimazole-Akrikhin intravaginally, absorption is 3-10% of the administered dose. High concentrations in vaginal secretions and low concentrations in blood persist for 48-72 hours. In the liver, they are rapidly metabolized to inactive metabolites.

    Indications for use:

    - genital infections caused by yeast-like fungi of the genus Candida and / or Trichomonas vaginalis (vulvovaginal candidiasis, trichomoniasis);
    - genital superinfections caused by microorganisms sensitive to clotrimazole;
    - sanitation of the birth canal before childbirth.

    Contraindications:

    Hypersensitivity to clotrimazole or excipients, in the first trimester of pregnancy. Avoid the use of tablets during menstruation. With care - lactation period.

    Application during pregnancy and lactation

    In clinical and experimental studies, it was not found that the use of the drug during pregnancy or during lactation has a negative effect on the health of a woman or fetus (child). However, the question of the advisability of prescribing the drug should be decided individually after consulting a doctor.

    Method of administration and dosage

    Locally. For intravaginal use only. Vaginal tablets are inserted into the vagina in the evening, as deep as possible, in the supine position with slightly bent legs, 1 vaginal tablet of 100 mg daily for 6 days. A second course of treatment is possible after consulting a doctor.

    Side effect

    Itching, burning and swelling of the vaginal mucosa, vaginal discharge, headache, gastralgia, frequent urination, intercurrent cystitis, burning sensation in the penis of a sexual partner, pain during intercourse.

    Overdose

    The use of the drug in high doses does not cause any reactions and conditions that are life-threatening. In case of unintended use of the drug (inside), the following symptoms are possible: anorexia, nausea, vomiting, gastralgia, liver dysfunction; rarely, drowsiness, hallucinations, pollakiuria, allergic skin reactions. There is no specific antidote. It is necessary to appoint activated carbon internally. If necessary, treatment is symptomatic.

    Interaction with other medicinal products

    When administered vaginally, Clotrimazole-Akrikhin reduces the activity of amphotericin B and other palienic antibiotics. With simultaneous use with nystatin, the activity of Clotrimazole-Akrikhin may decrease.

    special instructions

    To prevent urogenital reinfection, simultaneous treatment of sexual partners is necessary.

    In trichomoniasis, for more successful treatment, other drugs with a systemic effect (for example, oral metronidazole) should be used in conjunction with Clotrimazole-Akrikhin.

    With a simultaneous infection of the labia and adjacent areas (vulvitis candidiasis), additional local treatment with Clotrimazole cream should be carried out. During pregnancy, treatment with vaginal tablets should be carried out without an applicator.

    In patients with hepatic insufficiency, the functional state of the liver should be monitored periodically.

    If signs of hypersensitivity or irritation appear, treatment is discontinued.

    If there is no effect within 4 weeks, the diagnosis should be confirmed.

    Release form:

    Vaginal tablets 100 mg.
    6 tablets in a blister strip packaging. 1 blister strip along with instructions for use is placed in a cardboard box.

    Shelf life

    3 years 6 months Do not use after the expiration date!

    Storage conditions

    Store in a dry, dark place and out of reach of children, at a temperature not exceeding 25 ° C.

    Pharmacy dispensing:

    Dispensed without a doctor's prescription.

    Manufacturer / Organization accepting customer claims:

    Open Joint Stock Company "Chemical and Pharmaceutical Plant" AKRIKHIN "(JSC" AKRIKHIN "), Russia
    142450, Moscow region, Noginsky district, Old Kupavna, st. Kirov, 29.

    Registration number: R N001917 / 02

    Trade name of the drug: Clotrimazole-Akrikhin

    International name: Clotrimazole

    Dosage form: ointment

    Composition:
    100 g of ointment contain:
    active substance clotrimazole in terms of 100% substance -1 g;
    excipients propylene glycol - 12.5 g, methyl parahydroxybenzoate (nipagin) - 0.2 g, succinic acid - 0.5 g, sodium benzoate - 6 g, emulsion wax - 3 g, castor oil - 14 g, methyl cellulose - 3 g, distilled monoglycerides -1.5 g, purified water - up to 100 g.

    Description: The ointment is white or almost white in color with a weak specific odor.

    Pharmacotherapeutic group:
    antifungal agent.
    ATX code: D01AC01

    Pharmacological properties

    Pharmacodynamics.
    An antifungal agent from the group of imidazole derivatives for external use, reduces the synthesis of ergosterol, which is an integral part of the cell membrane of the microbial wall, and leads to a change in its structure and properties.
    In small concentrations, it acts fungistatically, and in large (more than 20 μg / ml) - fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

    It is active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and mold fungi (Candida spp., Torulopsis glabrata, Rhodotorula spp., Pityrosporum orbiculare).

    Pharmacokinetics.
    It is poorly absorbed through the skin and mucous membranes and practically does not have a systemic effect. It accumulates in the stratum corneum of the epidermis, penetrates into the keratin of the nails. The concentration in the deep layers of the epidermis is higher than the minimum inhibitory concentration for dermatophytes.


    Indications for use
    • fungal diseases of the skin, including skin folds and feet, caused by dermatophytes, yeast (Candida spp.), molds and other fungi and pathogens sensitive to clotrimazole: dermatomycosis, dermatophytosis, trichophytosis, epidermophytosis, microsporia, fungal candidiasis, interpalium paronychia;
    • mycoses complicated by secondary pyoderma, as part of complex therapy;
    • pityriasis versicolor, versicolor versicolor, erythrasma.
    Contraindications
    Hypersensitivity to potrimazole or excipients, pregnancy (I trimester), children under 2 years of age.

    Carefully
    Lactation period, pregnancy (II and III trimester).

    Method of administration and dosage
    Outwardly. Adults, in the absence of other appointments, are recommended to apply the ointment 2-3 times a day in a thin layer on previously cleaned and dry affected skin areas. A single dose on a palm-sized surface area - a column of ointment 5 mm long. Regular application of the ointment is essential for successful treatment.
    The duration of therapy is individual and depends on the severity and localization of the disease. To achieve full recovery, you should not stop treatment with the ointment immediately after the disappearance of acute symptoms of inflammation or subjective complaints.

    The duration of therapy should be about 4 weeks on average.

    Pityriasis versicolor heals mainly within 1-3 weeks, and erythrasma within 2-4 weeks.

    In children from 2 years of age, the drug is used in the doses indicated above.


    Side effects
    Local reactions: burning, swelling, irritation and peeling of the skin, paresthesias, erythematous rashes, blistering.
    Allergic reactions: itching, urticaria.

    Overdose
    Low systemic absorption of the active component of the drug when applied externally makes an overdose almost impossible.

    Interaction with other medicinal products
    Amphotericin B, nystatin, natamycin reduce the effectiveness of clotrimazole when used simultaneously.

    special instructions
    Avoid contact with the mucous membrane of the eyes.
    In patients with hepatic insufficiency, the functional state of the liver should be monitored periodically.
    If signs of hypersensitivity or irritation appear, treatment is discontinued.
    If there is no effect within 4 weeks, the diagnosis should be confirmed.
    In children, large surfaces should be avoided.