The action of ascorbic acid in pills for alcoholism. Instructions for pills with ascorbic acid Ascorbic acid instructions for use of pills

03.11.2020

Ascorbic acid or vitamin C is one of the most famous vitamins, since everyone knows about its benefits from an early age. As soon as a child falls ill with a cold, tea with lemon, fresh fruits, berries immediately come to his aid. In all this there is ascorbic acid, which forces the body to produce the required number of leukocytes and lymphocytes to fight against foreign cells. It is on their readiness that the speed of the body's fight against infection depends. For immunity to be strong, it is enough to consume 40 to 100 mg of vitamin C every day, it all depends on the person's age. In addition to the presence of vitamin C in food, ascorbic acid is synthetically produced at pharmaceutical plants.

Properties

The daily dose of ascorbic acid for a child is 40-75 mg, and for an adult - 75-100 mg. If the specified norms are not exceeded, then the body will work without failures and with the support of strong immunity. Everything is reasonable in moderation, if there is an overdose of ascorbic acid, that is, the likelihood of an allergic reaction. By itself, vitamin C is safe for health, it has a number of beneficial properties:

Increases the body's endurance;
Protects against viruses;
Accelerates the healing process of wounds, helps in the process of skin and bone regeneration;
Participates in the synthesis of good cholesterol, cholic acids and fats;
Takes part in the synthesis of vitamin E;
Promotes the production of red blood cells;
It has antioxidant properties;
Counteracts the oxidation process at the cellular level;
Minimizes the risk of harmful nitrosamines;
Has a bactericidal effect against a number of pathogens;
Cleans blood vessels from harmful cholesterol, preventing the development of atherosclerosis;
Participates in the production of hormones that reduce stress levels;
Removes toxins from the body;
Takes part in the production of collagen;
Accelerates the process of bile secretion;
Helps to normalize the exocrine function of the endocrine system;
Reduces intoxication, which is especially important for smokers;
It has a general strengthening effect on the entire body.

It is also worth mentioning the properties of vitamin C with different storage methods. If we talk about products that contain ascorbic acid, then it is better to give them a minimum heat treatment. If these are vegetables, fruits and berries, then it is better to eat them fresh, and not in the form of jam or jam. Also, vitamin C tends to break down when the product is exposed to light for a long time, it is also sensitive to the high importance of air and long-term storage.

Smokers should be aware that each cigarette smoked destroys up to 25 mg of ascorbic acid in the body, so people with such a bad habit should consume up to 100-125 mg of vitamin C per day.

Special attention should be paid to the properties of vitamin C in cosmetology. Ascorbic acid face masks have a range of miraculous properties :

Smooths out wrinkles and prevents their appearance;
Even out the complexion;
Improves skin firmness;
Normalize sebum production;
Reduce the amount of inflammatory elements on the skin;
Makes redness less noticeable
Fight swelling;
Get rid of pigmentation;
Prevents the appearance of new acne breakouts;
They have a bactericidal and sedative effect.

Almost everyone can use ascorbic acid for the face, the main thing is not to risk with such procedures in the presence of allergies. Ascorbic acid for acne has a quick and noticeable result, but frequent use of this substance can severely dry the skin. After such procedures, it is important to moisturize the skin well.

If you can't keep track of your diet, then vitamin C can be taken in the form of tablets or pills. The main thing is to know the permissible dosage and features of taking ascorbic acid.

Consumption rates

How to drink ascorbic acid correctly? To answer this question, you must first consult with your doctor. He should clarify whether the patient has contraindications to taking this vitamin. If everything is normal, then the doctor will prescribe the appropriate dosage.

The human body is designed in such a way that it does not independently produce ascorbic acid, so it must be obtained with food. At different ages, a person needs a different amount of this substance. Average consumption rates:

Children 0 to 6 months - 30 to 40 mg per day;
6 months to a year - 50 mg per day;
1-3 years - 40 mg per day;
4-8 years old - 45 mg per day;
9-13 - 50 mg per day;
14-18 - 50-60 mg per day;
For guys aged 19 and older - 90 mg per day;
For girls aged 19 and older - 75 mg per day.

When a woman is carrying a child, the level of this vitamin should be on average 100 mg per day. During lactation, the intake of ascorbic acid should be at the level of 120 mg per day.

If a person smokes or is often given to passive smoking, then the level of vitamin C should be raised by 35 mg above the norm, that is, up to 125-130 mg per day should be taken.

pharmachologic effect

How to take ascorbic acid so that there is only benefit from it? Before deciding to take this vitamin, you need to know what effect it has on the body. If we consider ascorbic acid from the pharmaceutical side, then this substance has the following effects:

Participates in the activation of metabolic processes;
Contributes to the normalization of the blood clotting process.
Reduces vascular permeability;
Helps increase the body's resistance to viruses;
Reduces the need for the synthesis of folic and pantothenic acid, some B vitamins;
Takes an active part in the production of proteins, lipids and serotonin;
Responsible for the rate of oxygen transport to cells;
Takes part in the synthesis of steroid hormones;
Increases capillary permeability;
Helps to store glycogen;
Takes part in the production of protein compounds;
Has a detox effect throughout the body;
Promotes the activation process of antibodies, which increases the level of protection against infections;
Slows down the production of histamine.

Ascorbic acid for children and adults has an effect on all organs and systems, as it penetrates into white blood cells and platelets. If you take about 200 mg of ascorbic acid, then about 140 mg is absorbed. If the dose is increased further, the absorption is reduced by almost half. When taken orally, ascorbic acid reaches its peak only after 4 hours. The biotransformation process takes place in the liver. Substances that are excreted from the body after taking this drug are excreted through the intestines, kidneys, sweat glands, and through breast milk.

Indications for use

Ascorbic acid for children and adults helps prevent a decrease in the activity of the immune system, but it is also prescribed for a number of other diseases:

Due to its powerful antioxidant properties, ampoules with vitamin C are often prescribed in the fight against bronchial asthma, as well as as a treatment for atherosclerosis. Ascorbic acid helps cleanse blood vessels. In the form of ampoules, this substance is administered only in cases where it is necessary to obtain a rapid increase in the level of vitamin C, or in the absence of the possibility of taking the tablet orally.

Instructions for use and doses

How much ascorbic acid can you take per day? The attending physician can answer this question, because the form of release of this vitamin plays an important role.

Tablet and dragee form

How to take ascorbic acid orally? Vitamin C, which comes in pill and pill form, is always best taken after meals. If you drink this form on an empty stomach, then there is a chance to worsen the condition of the stomach, because ascorbic acid will further increase the acidity of gastric juice. The tablets must be chewed thoroughly and washed down with water. Vitamin C is water-soluble, so the tablet can be crushed and added to juices, water or compotes.

For prevention purposes, it is better for adults to take from 50 to 100 mg of vitamin C per day. If there is an intention to start treatment, then the dose is increased from 150 mg to 500 mg per day. The amount of the drug varies depending on the diagnosis. The main thing is that the entire indicated daily dose should be divided into several doses - from 3 to 5 times.

For children, ascorbic acid in dragees, according to the instructions, should be taken in a volume of 100 to 300 mg per day. The maximum period for taking ascorbic acid in such volumes should not exceed 2 weeks.

If you drink ascorbic acid in the form of chewable tablets, then a daily dose of 250 mg should not be exceeded. The maximum duration of treatment with this form is 10-15 days.

Ampoule shape

Ascorbic acid in the form of an ampoule is administered intravenously either by jet or drip. For patients over 12 years of age, the dose is selected on an individual basis. But it should vary between 50-150 mg. If the patient is admitted to the hospital with poisoning, then the dosage is increased to 300 mg per day.

To find out the dose for a child under 12 years old, the calculation is carried out based on the patient's weight. For every kilogram of a child's weight, there are 5 to 7 mg of ascorbic acid. To find out the duration of treatment with this substance, it is necessary to know the patient's diagnosis and the complexity of his condition.

For adults, the maximum allowable dosage may be 200 mg of vitamin C per ampoule, and for a child - 100 mg.

If a solution of ascorbic acid is injected by the jet method, then this procedure should be done within 1-3 minutes. The drip method is carried out using intravenous infusion. The approximate injection rate is 30-40 drops in 60 seconds.

Ascorbic acid with glucose

In this form, vitamin C is prescribed for the treatment of very debilitated patients who have suffered an infectious disease. As a prophylaxis for an adult, it is allowed to take half or 1 tablet per day. For treatment purposes, the dosage is increased to 1.5-5 tablets per day.

Also, vitamin C in tandem with glucose is administered intravenously in order to prevent the development of pulmonary edema, infection.

Ascorbic acid with glucose is indispensable for pregnant women, because with its help they can slightly reduce the symptoms of toxicosis. The dose for a pregnant woman is prescribed only by a doctor, self-medication in this case is contraindicated.

Contraindications

The formula of ascorbic acid is not accepted by everyone, it is especially dangerous for people who are hypersensitive to this substance. Also, doctors do not recommend taking this vitamin in the presence of serious vascular pathologies. Ascorbic acid is contraindicated for those diagnosed with thrombosis or thrombophlebitis.

Doctors are wary of prescribing such a drug for people with the following diseases:

Diabetes;
Leukemia;
Hemochromatosis;
Diseases of the urinary system;
Fructose intolerance;
Oncological diseases;
Polycythemia.

Pediatricians do not recommend prescribing ascorbic acid for children in the form of pills under the age of 4 years. It is better to take this form from the age of 6. The child must understand that he is taking a drug. Reception of such funds should be carried out only under the supervision of adults. It is better to discuss contraindications to taking ascorbic acid with your doctor.

Side effect

If the dosage of ascorbic acid has been violated, then a number of side effects may appear. Pathologies can appear in different organs and systems. The most common side effects of vitamin C are as follows:

The likelihood of pathologies from the cardiovascular system increases, there are risks of leukocytosis, thrombosis or erythromenia.
The nervous system may react to this drug with weakness and dizziness. Especially often, these symptoms appear when the drug is administered too quickly through a vein.
When vitamin C is taken orally, there is a risk of diarrhea, nausea, vomiting.
From metabolic pathologies there is a risk of hypokalemia and sodium retention.
Vitamin C, if taken excessively, can provoke damage to the glomerular apparatus of the kidneys, as well as increase urine output.

Patients need to remember that after the injection of the solution, a feeling of heat appears under the skin. After this procedure, the skin may hurt for a while.

Overdose

Ascorbic acid vitamins are perceived by most people as a harmless drug, but in fact, if taken incorrectly, an overdose can occur. It occurs when more than 1 g of ascorbic acid is taken every day for a long time. An overdose of vitamin C can manifest itself as follows:

Nausea;
Headache and dizziness;
Sleep problems;
Increased excitability of the nervous system;
The appearance of ulcers on the mucous membrane of the esophagus;
Diarrhea;
Vomiting;
Development of oxalose;
Gastritis;
Moderate pollakiuria.

We must not forget that ascorbic acid is also capable of provoking hypertension in large volumes. This substance affects the composition of the blood, thereby disrupting its clotting process. If vitamin C is administered intravenously, then high dosages of this substance can develop erythrocytolysis. In pregnant women, with the introduction of ascorbic acid in large doses in the form of injections, the risk of abortion increases sharply. You can die from ascorbic acid if you take about 20-30 g per day.

Features of reception

Ascorbic acid in the amount of 50 mg per day for an adult is not capable of harm, but there are cases when a doctor should prescribe the permissible dosage of this drug. Manufacturers in the instructions for the drug indicate that vitamin C does not affect the speed of reactions, so it can be taken before driving. The main thing is not to prescribe this remedy to children over 4 years of age. To protect your health, you should adhere to the following rules:

Do not self-medicate, take ascorbic acid strictly as directed by your doctor,
If vitamin C needs to be taken for a long time, then it is worth checking the condition of the kidneys, pancreas and blood pressure periodically.
If the patient has pathologies of the urinary system, then more than 1 g of vitamin C should not be taken per day.
A large dosage of ascorbic acid is contraindicated in people with increased blood clotting.
If a patient is diagnosed with a high concentration of iron in the body, then this drug must be taken in a minimum amount.
Dragee should not be washed down with mineral water, as the alkaline environment reduces the absorption of vitamin C.
Drinking ascorbic acid is not worth it if you plan to donate blood for testing glucose, bilirubin, transaminases, lactate dehydrogenases.
Due to its stimulating effect, ascorbic acid should not be taken in the afternoon.

So that this vitamin does not harm the body, it is also important to pay attention to its shelf life. In tablet form, ascorbic acid can be stored for 3 years. In the form of a solution and dragee, vitamin C retains its properties for 1.5 years.

Analogs

Often ascorbic acid is produced under the name of the same name, pharmaceutical companies specify only the form of release. In pharmacies, you can buy ascoribinum at the following prices:

Ascorbic acid, dragee 100 pcs, Sesana, RF - 12 rubles;
Twist, chewable tablets, orange, 10 pcs, Pharmaceutical industry, RF - 8 rubles;
Supravit, effervescent tablets, Bulgaria - 199 rubles;
Ascorvit, NaturProductPharma, Poland - 159 rubles;
Ascorbinka, powder, 30 pack., Ecopharm RF, - 116 rubles.

You can buy vitamin C from different manufacturers, but at the price, the cheapest options will be those vitamins that were produced by national pharmaceutical companies.

Ascorvite or Ascorbic acid - which one to choose?

There is no big difference between these drugs, because Ascorvit is ascorbic acid in powder form. This medicinal product is produced in amounts of 500 mg and 1000 mg. Such a high dosage is not very convenient for self-administration, since each time it will be necessary to weigh the required amount of powder. When buying ascorbic acid in this form of release from other manufacturers, you can choose the required volume.

Ascorbic acid and Biovital - which is better?

Biovital is ascorbic acid made in the form of a chewable tablet. This option for taking the drug is more convenient. In addition, Biovital contains 247 mg of ascorbic acid and 284 mg of sodium ascorbate, which fully corresponds to 500 mg of ascorbic acid. Biovital is better than ordinary ascorbic acid, as this preparation contains: iron, folic acid, hawthorn and motherwort extracts.

This version of the drug is ideal for strengthening the health of women of different ages; a particular positive effect is observed when taking the drug during premenopause and menopause.

Ascorbic acid and Asvitol - which is cheaper?

Asvitol is available in the form of tablets, one pill contains 200 mg of ascorbic acid. The average price for Asvitol varies between 50-55 rubles for 20 tablets. For 10 tablets of ordinary ascorbic acid in the form of tablets, you will have to pay an average of 7 to 20 rubles.

Ascorbic acid and Vitamin C - how are they different?

Vitamin C is found only in vegetables and fruits, and ascorbic acid can be produced synthetically. If in vitamin C all its components are synergistic, that is, they complement each other's action, then this cannot be said about ascorbic acid. You can get truly complete vitamin C only from food. To strengthen the immune system and increase the general tone of the body, it is better to eat right, eat only fresh vegetables and fruits, and also drink freshly squeezed juices.

Vitamins. Ascorbic acid (vitamin C). ATX code А11G А01.

Pharmacological properties

Pharmacodynamics
Ascorbic acid (vitamin C) belongs to the group of water-soluble vitamins. Ascorbic acid (vitamin C) has pronounced reducing properties. It takes part in redox reactions, regulation of carbohydrate metabolism, affects the exchange of aromatic amino acids, thyroxine metabolism, biosynthesis of catecholamines, steroid hormones and insulin, is necessary for blood clotting, collagen and procollagen synthesis, regeneration of connective and bone tissue. Improves capillary permeability. Promotes the absorption of iron in the intestine and takes part in the synthesis of hemoglobin. Increases nonspecific resistance of the body, has antidote properties. Deficiency of vitamin C in food leads to the development of hypo- and avitaminosis C, since this vitamin is not synthesized in the body.
Pharmacokinetics
Suction... It is absorbed in the gastrointestinal tract (GIT) (mainly in the jejunum). With an increase in the dose to 200 mg, up to 70% is absorbed; with a further increase in the dose, absorption decreases to 50-20%. Diseases of the gastrointestinal tract (peptic ulcer and 12 duodenal ulcer, constipation or diarrhea, helminthic invasion, giardiasis), the use of fresh fruit and vegetable juices, alkaline drinks reduce the absorption of ascorbic acid in the intestine.
The concentration of ascorbic acid in plasma is normally approximately 10-20 μg / ml, the reserves in the body are about 1.5 g when taking the daily recommended doses and 2.5 g when taking 200 mg / day. The time to reach the maximum concentration (Tcmax) after oral administration is 4 hours.
Distribution... Connection with plasma proteins - 25%. It easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; crosses the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficient conditions, the concentration in leukocytes decreases later and more slowly and is considered as a better criterion for assessing deficiency than plasma concentration.
Metabolism... It is metabolized mainly in the liver into deoxyascorbic acid and further into oxaloacetic acid and ascorbate-2-sulfate.
Withdrawal... It is excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolites.
When high doses are prescribed, the rate of excretion increases dramatically. Smoking and drinking ethanol accelerate the breakdown of ascorbic acid (conversion into inactive metabolites), dramatically reducing body stores. It is excreted during hemodialysis.

Indications

Prevention and treatment of vitamin C deficiency.
Conditions of increased need for ascorbic acid: a period of intensive growth, unbalanced nutrition, increased mental and physical exertion, a period of convalescence after severe illness, feverish conditions against the background of acute respiratory diseases, acute respiratory viral infections, long-term chronic infections

Contraindications

Hypersensitivity to ascorbic acid or to any of the drug excipients. Thrombosis, tendency to thrombosis, thrombophlebitis, diabetes mellitus, severe kidney disease. Urolithiasis - when using doses over 1 g per day. Fructose intolerance, glucose-galactose malabsorption syndrome. Children under 6 years old.

Interaction with medicinal products

Oral ascorbic acid increases the absorption of penicillin, tetracycline, iron; promotes the absorption of aluminum in the intestine, which should be taken into account while treating with antacids containing aluminum.
The simultaneous use of vitamin C and deferoxamine increases the tissue toxicity of iron, especially in the heart muscle, which can lead to decompensation of the circulatory system. Vitamin C can be used only 2 hours after deferoxamine injection.
Long-term use of large doses by persons who are treated with disulfiramine inhibits the disulfiram-alcohol reaction.
High doses of the drug reduce the effectiveness of tricyclic antidepressants, antipsychotics - phenothiazine derivatives, tubular reabsorption of amphetamine, disrupt the excretion of mexiletine by the kidneys, and affect the resorption of vitamin B12.
Ascorbic acid increases the total clearance of ethyl alcohol.
The drug reduces the toxicity of sulfa drugs, reduces the effectiveness of heparin and indirect anticoagulants.
Vitamin C increases the excretion of oxalate in the urine, thus increasing the risk of oxalate stones in the urine, and increasing the risk of crystalluria when treated with salicylates
Medicines of the quinoline series, calcium chloride, salicylates, corticosteroids, with prolonged use, reduce the reserves of ascorbic acid in the body.
The absorption of ascorbic acid is reduced with the simultaneous use of oral contraceptives, the use of fruit or vegetable juices, and alkaline drinks.
If you are taking any other medications, consult your doctor about the possibility of using the drug.

Application features

Before starting treatment, consult your doctor!
When using high doses or with prolonged use of the drug, it is necessary to monitor renal function and blood pressure, as well as pancreatic function. The drug should be used with caution in patients with a history of kidney disease.
In case of urolithiasis, the daily dose of ascorbic acid should not exceed 1 g. Large doses of the drug should not be prescribed to patients with increased blood clotting.
Since ascorbic acid increases iron absorption, its use in high doses can be dangerous for patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia. Patients with a high iron content in the body should use the drug in minimal doses.
The simultaneous use of the drug with an alkaline drink reduces the absorption of ascorbic acid, so you should not drink it with alkaline mineral water. Also, the absorption of ascorbic acid can be impaired in case of intestinal dyskinesia, enteritis and achilia.
Use with caution for the treatment of patients with glucose-6-phosphate dehydrogenase deficiency.
Ascorbic acid as a reducing agent can affect the results of laboratory tests, for example, when determining the content of glucose, bilirubin in the blood, the activity of transaminases, lactate dehydrogenase.
Since ascorbic acid has a mild stimulating effect, it is not recommended to use the drug at the end of the day. In connection with the stimulating effect of ascorbic acid on the formation of corticosteroid hormones, when using the drug in large doses, control of renal function and blood pressure is needed.

Application during pregnancy or lactation

A lack of vitamin C in the diet of pregnant women can be dangerous for the fetus, however, its use in large doses can also negatively affect the development of the fetus, therefore, during pregnancy, the drug is used only in accordance with the dosage recommendations and the doctor's prescription.
Ascorbic acid passes into breast milk, therefore, during breastfeeding, vitamin C should be taken under the supervision of a doctor, in accordance with the recommended doses.

The ability to influence the reaction rate when driving or using other mechanisms

Does not affect.

Application in children

The drug should be used in children from 6 years of age.

Method of administration and dosage

The drug is administered orally after meals.
For prophylaxis, adults and children over 14 years old should take 2-4 tablets (50-100 mg) per day; children aged 6 to 14 years - 1-2 tablets (50 mg) per day.
Therapeutic doses for children over the age of 14 and adults are 2-4 tablets (50-100 mg) 3-5 times a day, for children from 6 to 10 years old - 4 tablets (100 mg) 2-3 times a day day, children aged 10 to 14 years - 4-6 tablets (100-150 mg) 2-3 times a day.
The dosage and course of treatment depends on the nature and characteristics of the course of the disease and is determined by the doctor.

Overdose

Ascorbic acid is well tolerated. It is a water-soluble vitamin and excessive amounts are excreted in the urine.
Symptoms... With prolonged use of vitamin C in large doses, it is possible to suppress the function of the insular apparatus of the pancreas, which requires monitoring the state of the latter. Overdose can lead to a change in renal excretion of ascorbic and uric acids during urine acetylation with the risk of precipitation of oxalate calculi.
The use of large doses of the drug can lead to vomiting, nausea or diarrhea, which disappear after its withdrawal.
Treatment... Symptomatic therapy.

Description of Ascorbic Acid

Ascorbic acid is an organic chemical compound that is in demand for the normal functioning of the human body and belongs to the group of vitamins.

Ascorbic acid composition

One dragee contains 0.05 g of ascorbic acid, as well as form-forming substances - talc, petroleum jelly, beeswax, flavor.

The form

Ascorbic acid dragee

1 tablet contains 50 mg of active ingredient.

Ascorbic acid in ampoules

It is produced in the form of a 10% solution of 1, 2 and 5 ml, and in the form of a 5% solution of 1.2 and 5 ml. Dosage for the treatment of adults: 1-3 ml of a 5% solution. A single dose is within 0.2 g, a daily dose is 0.5. The dosage for the treatment of children is 1-2 ml of a 5% solution per day. The course of therapy is 2-3 weeks.

Storage of the drug

Ascorbic acid is stored in a dark room, at a temperature below 25 C. Storage duration 1.6 years.

Physico-biological significance

Due to the lack of mechanisms for the formation of vitamin C in the human body, it is synthesized in the liver and tissues, and comes only from the outside. Exceeding the permissible dose does not cause complications. In such cases, the elimination of the symptoms of hypovitaminosis occurs faster. Vitamin C is an important component of chemical reactions: hydroxylation, amidation, oxidation of folic acid, breakdown of drugs in the liver parenchyma, hydroxylation of dopamine.

The drug affects the formation of hormones - oxytocin, cholecystokinin, steroids, antidiuretic hormone. Increases the absorption of iron in the intestine, restores ferric iron to bivalent. It has an important effect on the formation of bones and connective tissue, capillary endothelium - proteoglycans, collagen. The use of vitamin C in low doses enhances the activity of deferoxamine, which is important in case of an overdose with iron preparations.

Ascorbic acid neutralizes free radicals, takes part in redox reactions, increases immune properties, and promotes regeneration.

Pharmacokinetics

The drug is absorbed mainly in the small intestine. With an increase in a single dose of more than 200 mg, the ability to be absorbed decreases. Ascorbic acid is 25% bound to blood plasma carrier proteins.

Also, the percentage of the absorbed drug decreases when:

Diseases of the stomach, intestines and other organs of the digestive system (for example, with gastric ulcer and / or duodenal ulcer)
The use of certain foods - freshly squeezed juices of vegetables or fruits, alkaline mineral waters.

The supply of vitamin C in the body is about 1.5 g. 4 hours after taking the drug, its content in the blood reaches its maximum. The usual plasma concentration is 10-20 μg / ml.

The drug passes freely through the membrane of leukocytes, platelets and other tissues. Most of all, ascorbic acid accumulates in glandular organs, immune cells, liver parenchyma and lens. Able to cross the placenta. Cleavage occurs in hepatocytes. First, the drug is converted into deoxyascorbic acid, and then into oxaloacetic acid and ascorbate-2-sulfate.

The excretion of split products is carried out through a renal filter, with intestinal contents, with sweat, breast milk. A small percentage of ascorbic acid is excreted without metabolic degradation in its initial form. Vitamin C reserves decrease with alcohol consumption and smoking, hemodialysis sessions. Excretion from the body occurs faster if the permissible dose is exceeded.

Indications for the use of Ascorbic acid

The main application of the drug is in the case of vitamin C hypo- and vitamin C deficiency. It is required to prescribe the drug, with its increased consumption: artificial feeding, pregnancy, intensive body growth, increased physical and intellectual activity. Also, ascorbic acid is prescribed for increased excretion or consumption of vitamin C - alcoholism, smoking, severe chronic diseases, stress, burn disease, fever, chronic infectious processes. Insufficient intake of vitamin with food requires the appointment of the drug. During therapy with deferoxamine, the consumption of vitamin C increases and its exogenous intake is necessary. The presence of idiopathic methemoglobinemia requires the appointment of the drug.

Contraindications

It is forbidden to prescribe the drug for diabetes mellitus, a tendency to form blood clots, thrombophlebitis. Also, reception is not recommended in the presence of individual intolerance to the components of the drug. Do not use the drug for such hereditary enzymopathies - sucrose, isomaltase, fructose deficiency, glucose-galactose malabsorption. Use with caution in case of increased urinary salt excretion, renal failure, hemochromatosis, hereditary blood diseases and anemias of various origins, erythrocytosis, thrombocytosis, leukocytosis, blood cancer, progressive malignant diseases.

Ascorbic acid instructions for use

The dose selection is based on the patient's age. Also take into account the level of saturation of the body with vitamin C, the severity of clinical symptoms.

For prophylaxis, the following dosages of ascorbic acid are used:

For adult patients, 0.05-0.1 g (or 1-2 pills) are used per day. Children, starting from the age of 5 years, are prescribed 0.05 g (or 1 tablet) per day. Doses for pregnant and lactating women are 0.3 g (which corresponds to 6 tablets) per day. At this dose, the intake is carried out for about 2 weeks. Reception continues, switching to a dose of 100 mcg (or 2 tablets per day).

Therapeutic doses are prescribed with the development of vivid clinical symptoms. Adults need to take 50-100 mcg three times a day. You can increase the number of doses up to 5 per day. Children use the same doses - 1-2 tablets three times a day. The drug in the form of pills is taken by children from 5 years of age.

Ascorbic acid: how much per day?

Doses of the drug are selected according to the patient's age, body weight and the results of clinical and laboratory examinations.

Reception of ascorbic acid should be carried out after meals, from 3 to 5 times a day, depending on the indications. Doses of the drug for adults 1-2 tablets 3 times a day. Children from the age of five - 1 tablet. For prevention purposes, the above doses are taken once a day.

Doses for pregnant and lactating women - 0.3 g (or 6 tablets) per day for 10-15 days, then switch to a dose of 0.1 g (or 2 tablets per day).

Ascorbic acid is taken orally after meals.

Therapeutic doses:

For adults - 0.05-0.1 g (or 1-2 pills) 3-5 times a day;

For children from 5 years old - 0.05-1 g (or 1-2 tablets) 2-3 times a day.

Ascorbic acid during pregnancy

Doses of Ascorbic acid are selected individually, taking into account the general condition of the patient and laboratory parameters. Doses for pregnant and lactating women are about 300 mg (or 6 pills) per day for 2 weeks, then switch to a dose of 0.1 g, which corresponds to 2 pills per day.

The minimum dose of taking the drug in the second half of pregnancy is 60 mg per day, during lactation - 80 mg. A sufficient amount of ascorbic acid taken by the mother prevents the development of vitamin C hypovitaminosis in an infant.

Ascorbic acid is taken orally after meals.

Ascorbic acid for children

Doses of the drug depend on the age of the patient and the saturation of the body with vitamin C.

Preventive doses: for children from 5 years old - 0.05 g (or 1 tablet) per day. Ascorbic acid is taken orally after meals.

Therapeutic doses: for children from 5 years old - 0.05-1 g (or 1-2 pills) 2-3 times a day.

Overdose

If the daily dose of the drug is exceeded by more than 1 g, dyspeptic symptoms (heartburn, diarrhea) may occur. In patients with hereditary pathology - glucose-6-phosphate dehydrogenase deficiency, hemolysis may develop. You may also experience red urine and difficulty urinating. When these symptoms occur, symptomatic treatment is carried out, diuretic therapy is used.

Interaction with drugs

Ascorbic acid has the ability to increase the content of benzylpenicillin and tetracyclines, acetylsalicylic acid in the body fluid. Also, vitamin C slows down the excretion of sulfonamides, alkaloids. The drug increases the absorption in the wall of the small intestine of such drugs: iron, as it converts ferric iron to bivalent. Concomitant administration with deferoxamine leads to increased iron excretion.

The percentage of absorbed drug decreases when:

Diseases of the digestive system (for example, with gastric ulcer and duodenal ulcer)
Dyspeptic disorders (constipation, diarrhea)
The presence of helminthiasis (helminthic invasion, giardiasis)
Eating these types of foods, freshly made juices from vegetables, fruits, and liquids with an alkaline reaction.
Taking oral contraceptives
The use of acetylsalicylic acid.

The risk of salt formation in the urine increases with concomitant treatment with salicylates. The effect of oral contraceptives decreases, due to a decrease in their concentration in plasma. The elimination of ethanol from plasma is accelerated. The consumption of ascorbic acid from the depot is increased by such drugs: fluoroquinolones, salicylates, calcium chloride and glucocorticosteroids. At the same time, the use of the above drugs should be long-term.

Vitamin C reduces the chronotropic effect of isoprenaline. High doses of the drug increase the excretion of mexiletine by the kidneys. Ascorbic acid neutralizes the effects of antipsychotic drugs, amphetamine, tricyclic antidepressants. Barbiturates and primidone enhance the excretion of the drug through the renal filter.

Adverse reactions

They appear quite rarely. These may include:

Side effects from the nervous system (mainly central) - fatigue, headache, weakness; when using high doses - an increase in general excitability, sleep inversion.
From the gastrointestinal tract - nausea, vomiting, pain in the upper abdomen, diarrhea.
Impact on carbohydrate metabolism - glucosuria, hyperglycemia.
From the side of the kidneys - the formation of stones, fluid retention in the body.
Allergic manifestations - skin rash, itchy skin, Quincke's edema, anaphylactic shock.
From the circulatory system - microangiopathy, myocardial dystrophy, increased blood pressure.
Changes in blood counts - leukocytosis, erythropenia, thrombocytosis.
Changes in the metabolism of trace elements: a decrease in the content of potassium ions in the blood, a violation of the metabolism of zinc and copper.

special instructions

Since ascorbic acid affects the synthesis of hormones, it is important to conduct periodic studies of renal function, blood glucose levels and monitor blood pressure indicators. Patients with increased concentration of ferum in organs and tissues require correction of the dose of ascorbic acid in the direction of its reduction. During the course of the tumor process, the drug can accelerate the appearance of metastases.

Vitamin C has no effect on blood sugar laboratory tests, liver function tests and other tests.

Impact on transport management

Ascorbic acid has an effect on the speed of motor reactions when driving and interacting with other mechanical devices that require high concentration of attention.

Ascorbic acid price

The cost of the drug varies between 8-16 rubles.

Ascorbic acid reviews

Vadim: this drug is known to everyone from childhood. In kindergarten, it was given to every child. Now I buy such a drug for children. I am sure that the products currently on the market do not have the required amount of minerals and vitamins. And only diet to correct the lack of ascorbic acid is not possible. Taking the drug should be strictly in accordance with the scheme specified in the annotation to the drug. If the doses are exceeded, the tooth enamel may be damaged. Taking the drug on an empty stomach is fraught with pain in the stomach. Our children also love these yellow jelly beans, as I do. When the period of viral infections comes, we have a jar of ascorbic acid in our medicine cabinet. The decent price and the minimum amount of chemical additives and non-natural ingredients are good news. I advise everyone.

Alyona: Vitamin C has many positive effects and most importantly, it strengthens the immune system. Also, the drug has antioxidant properties, which means it slows down the aging process of the body and prevents cancer. For normal life, a person needs about 1 g of ascorbic acid per day. Not everyone consumes such an amount of vegetables in the cold season. Therefore, in autumn and winter, our immunity decreases and we get sick. I buy the drug all the time and enjoy its effect.

Similar instructions:

Ascorbic acid (vitamin C) is not formed in the human body, but comes only with food.

Pharmacological effects: in quantities significantly exceeding the daily requirement (90 mg), it has almost no effect, except for the rapid elimination of the symptoms of hypo- and avitaminosis (scurvy).

Physiological functions: is a cofactor of some hydroxylation and amidation reactions - it transfers electrons to enzymes, supplying them with a reducing equivalent. Participates in the reactions of hydroxylation of proline and lysine residues of procollagen with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), oxidation of lysine side chains in proteins with the formation of hydroxytrimethyllysine (in the process of kartytite synthesis), oxidation of folic acid to folinic acid, drug metabolism and hydroxylation in liver microsomes dopamine with the formation of norepinephrine.

Increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and cholecystokinin. Participates in steroidogenesis in the adrenal glands;

Restores Fe3 + to Fe2 + in the intestine, promoting its absorption. The main role in tissues is participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and capillary endothelium.

In low doses (150-250 mg / day orally), it improves the complexing function of deferoxamine in chronic intoxication with iron preparations, which leads to increased excretion of the latter.

Ascorbic acid actively participates in many redox reactions, has a nonspecific general stimulating effect on the body. Increases the adaptive capacity of the body and its resistance to infections; promotes regeneration processes.

www.vidal.ru

Ascorbic acid dragee instruction

Ascorbic acid dosage

Ascorbic acid is prescribed in the following doses:

Preventive

children - 25 mg per day;
adults - 50-100 mg per day;

Therapeutic

children - 50-100 mg per day;
adults - 150-200 mg per day;
pregnant and lactating mothers - 250-300 mg per day.

Ascorbic acid dragee composition

1 tablet contains 50 mg of ascorbic acid in terms of pure substance.

Additional components: sugar, molasses, talc, yellow wax, orange flavor, mineral oil, E 104 dye.

Release form

It is produced in the form of spherical dragee, yellow, with a uniformly colored surface.

Vitamin C preparations

Ascorbic acid dragees - pharmacological action

Ascorbic acid is a powerful antioxidant. Protects cell walls from the damaging effects of free radicals by controlling redox reactions. Ascorbic acid affects the following body systems:

Immune.

stimulation of immunity;
increasing the body's resistance to infectious diseases;
reducing the manifestations of inflammation and allergies;
participation in the restoration of antioxidants - vitamins A and E.

Endocrine.

stimulation of hormone synthesis;
increased excretory activity of the pancreas;
stimulation of the hormonal activity of the thyroid gland.

Digestive.

stimulation of the synthesis of building proteins in the liver;
participation in the formation of digestive enzymes;
increased anti-toxic activity of the liver;
stimulation of bile secretion.

Cardiovascular and circulatory systems.

increasing the bioavailability of iron, which is necessary for the formation of hemoglobin;
lowering the level of "bad" cholesterol in the blood;
increased blood clotting;
normalization of the permeability of small vessels.

Indications for use

Ascorbic acid in dragees is indicated for use in such cases:

Indications

hypo- and avitaminosis C;
period of intensive growth;
monotonous and unbalanced diet;
hard mental and physical labor;
the recovery period after illnesses and operations;
alcoholic, nicotine and drug addiction;
stress and depression;
pregnancy and breastfeeding;
poisoning with iron preparations;
anemia;
hemorrhagic diathesis;
blood clotting disorders;
infectious diseases;
systemic intoxication;
poorly healing wounds and fractures.

Contraindications

Taking ascorbic acid in pills is contraindicated in the following cases:

thrombophlebitis;
predisposition to blood clots;
diabetes;
hypersensitivity to the components of the drug;
acute renal failure;
exacerbation of urolithiasis;
intolerance to fructose.

Side effects

In rare cases, taking ascorbic acid in dragees can cause allergic reactions. On the part of certain body systems, the following symptoms can be observed:

headache;
weakness and oppression;
insomnia;
excessive excitability.

Digestive.

nausea and vomiting;
diarrhea;
inflammation of the mucous membrane of the stomach and intestines;
painful abdominal cramps.

Endocrine.

decrease in the endocrine function of the pancreas;
increased blood sugar levels.

Cardiovascular and circulatory system.

blood clots;
increased blood pressure;
myocardial dystrophy.

Laboratory indicators may change - the content of platelets, prothrombin, sodium and neutrophilic leukocytes in the blood will increase, and the number of erythrocytes and potassium will decrease.

How to take ascorbic acid in pills - special instructions

Ascorbic acid stimulates the adrenal cortex, so blood pressure and kidney health should be monitored while taking.

With a long course, you need to monitor the endocrine function of the pancreas. With a high content of iron in the blood, ascorbic acid is prescribed in minimal dosages.

In patients with rapidly growing tumors, the drug can accelerate the pathological process. Taking ascorbic acid distorts the results of laboratory tests.

Ascorbic acid - instructions for interacting with other drugs

With the simultaneous use of ascorbic acid in dragees with other drugs, the following may be observed:

an increase in the blood concentration of antibiotics of the penicillin and tetracycline group;
decreased effectiveness of drugs that reduce blood clotting;
decrease in the bioavailability of ascorbic acid when taking oral contraceptives and alkaline solutions;
sulfonamides and salicylic acid increase the risk of urine crystals;
glucocorticosteroids and calcium preparations reduce the content of ascorbic acid in the body;
the effectiveness of antidepressants decreases.

Ascorbic acid dragee instructions for use

Ascorbic acid is taken orally after meals in doses prescribed by the doctor. For children, pills can be dissolved in water and given as a drink.

Overdose

With an overdose of ascorbic acid, the following is observed:

abdominal pain;
nausea;
vomiting;
diarrhea;
bloating;
rash;
overexcitability of the nervous system;

Taking in large doses over a long period of time can cause a decrease in insulin production and the formation of stones in the bladder. In case of an overdose, it is necessary to flush the stomach, take sorbents and immediately consult a doctor.

Terms of sale

Sold in pharmacies without a prescription.

Storage conditions

Store in its original packaging, in a dark place out of the reach of children, at a temperature not exceeding 25 ° C.

Shelf life

Stored for 18 months.

Reviews

The overwhelming majority of consumer reviews confirm the appearance of the indicated pharmacological action after a course of treatment with ascorbic acid in pills. The incidence of side effects coincides with the data stated in the instructions.

kalorizator.com

Ascorbic acid: instructions for the use of vitamin C in pills, indications, dosage

What is the composition of ascorbic acid and in what form it is produced. In what cases it is prescribed and how to choose a dosage.

Ascorbic acid (vitamin C) is a substance that the body needs to form collagen, strengthen the structure of bone tissue, capillaries and teeth. The element is involved in the metabolism of tyrosine, redox reactions, the breakdown of carbohydrates, the production of proteins and lipids.

Also, ascorbic acid is an irreplaceable element of cellular respiration. It reduces the need for tocopherol, retinol, vitamins B1 and B2, pantothenic and folic acid. Vitamin C works to strengthen the immune system, iron absorption and antioxidant functions. Below are the subtleties of taking and dosing ascorbic acid, instructions for using the drug in the form of pills (50 mg).

Composition and forms

Today ascorbic acid is available in the form:

Tablets - 25 and 50 mg (glucose is added to some drugs).
Dragee - 50 mg.
Oral solution - 2.5 g.
Solution for injection (intramuscular and intravenous).

The most popular form of vitamin C is dragee, which contains:

Ascorbic acid - 0.05 grams;
Additional elements are wheat flour, starch syrup, sugar and sunflower oil. Beeswax, fragrances, talc and dyes are also added.

The composition of the auxiliary elements may vary - here a lot depends on the manufacturer of the drug.

Pharmacokinetics

Ascorbic acid (vitamin C) is a substance that has a multifaceted effect on the human body:

Improving blood clotting.
Restoration of body cells.
Participation in oxidative as well as reduction reactions.
Regulation of amino acid and carbohydrate metabolism.
Help in the biosynthesis of catecholamines and carbohydrate metabolism.
Biosynthesis of insulin and steroid hormones.
Procollagen and collagen production.
Regeneration of bone and connective tissue.
Absorption of iron from food.
Production of hemoglobin and normalization of blood composition.
Improving capillary permeability, which reduces the risk of developing cardiovascular diseases.
Increase in nonspecific resistance of the organism.
Antioxidant properties.

Lack of ascorbic acid leads to the development of vitamin C deficiency due to the body's inability to synthesize this vitamin on its own.

After consuming vitamin C pills, it passes into the small intestine, where ascorbic acid is absorbed. Deterioration of the assimilation process of a substance is possible in the following cases:

intestinal dyskinesia;
achilia;
enteritis;
giardiasis;
helminthic invasion;
drinking alkaline drinks;
intake of fruits and fresh vegetable juices.

The highest concentration of the drug is achieved four hours after ingestion. The peculiarity of the substance is its rapid penetration into platelets, leukocytes, and then into all tissues of the human body. After that, the substance accumulates in the following parts of the body:

the back of the pituitary gland;
ocular epithelium;
liver;
ovaries;
intestinal wall;
adrenal cortex;
intermediate cells of the seminal glands;
spleen;
pancreas and thyroid gland;
heart and muscles.

The substance is metabolized primarily in the liver, transforming into deoxyascorbic acid, and then into dykeouglonic and oxaloacetic acids. Excess products (metabolites and ascorbate) are excreted in urine and feces.

Part of the vitamin C passes into the mother's breast milk, which should be taken into account during the nursing period. In the case of taking the supplement at an increased dosage, when the concentration increases to 1.4 mg / deciliter or more, the excretion of the drug is also enhanced. However, accelerated withdrawal often persists after the supplement is completed.

Indications for use

Vitamin C in pills is prescribed in the following cases:

Treatment or prevention of vitamin C deficiency (hypo- and avitaminosis).
Excessive stress (mental and physical).
A condition when the body needs an increased volume of ascorbic acid.
Diets or poor nutrition.
Periods of active growth.
As part of a comprehensive treatment for alcoholism.
Long-term ongoing chronic infections.
Chronic intoxication with iron-containing drugs. The need for vitamin C often arises in combination therapy with deforoxamine.
Nicotine addiction.
Burn diseases.
Idiopathic methemoglobinemia.
Pregnancy, postoperative period.
Excessive stress associated with work or household troubles. Perhaps the appointment of ascorbic acid for disorders of the central nervous system.
Feverish conditions, manifesting themselves against the background of long-term respiratory diseases, as well as viral infections.

Dosage

Despite the free sale and safety of the drug, it is important to know how to take vitamin C in pills and strictly follow the recommended dosage. Reception is carried out inside, after eating. The dosage is as follows:

For prevention:
- Adults - 50-100 mg per day (1-2 pills).
- Children over the age of five - 50 mg per day (1 tablet).
For medicinal purposes:
- Adults - 50-100 mg (one serving), 3-5 times a day.
- Children aged five years or more - 50-100 mg (1-2 tablets). The frequency of admission is 2-3 times a day.
Pregnancy and lactation period. The first 1.5-2 weeks are taken at 300 mg (6 tablets) per day, after which 100 mg (2 tablets) per day.

The maximum need for ascorbic acid in the 2-3 trimester of pregnancy is 50-60 mg. During the feeding period, it is important that 80-100 mg of vitamin C enter the body. This is enough to prevent a lack of vitamin C in a baby during infancy. During lactation, it is important to control the amount of vitamin intake and avoid overdose, despite the lack of evidence of a negative effect on the child.

During pregnancy, ascorbic acid quickly passes through the placental barrier, so that the fetus adapts more quickly to higher dosages. After a newborn child may have a withdrawal reaction. To avoid problems, the dosage of vitamin C during pregnancy must be tightly controlled.

Overdose and side effects

In case of prolonged use of the drug at a dosage exceeding 1 gram per day, the following problems are possible:

diarrhea;
heartburn;
difficulty urinating;
urine staining red;
hemolysis.

Overdose treatment is carried out taking into account the current symptoms. First of all, it is recommended to stop taking the drug, as well as limit the use of foods that contain vitamin C.

During the reception, the following side effects are possible:

Malfunctions of the central nervous system:
- feeling tired;
- headaches;
- sleep disturbance;
- cNS excitability.
Disruption of the urinary system:
- hyperoxalaturia;
- the formation of calcium oxalate;
- the formation of urinary stones.
Digestive system problems:
- vomiting;
- nausea;
- irritation of the gastrointestinal mucosa;
- stomach cramps;
- diarrhea.
Allergic manifestations:
- rash on the skin;
- anaphylactic shock.
Malfunctions of the endocrine system (associated with a malfunction of the insular apparatus):
- hyperglycemia;
- glucosoria.
Disruption of the cardiovascular system:
- myocardial dystrophy;
- microangiopathy;
- increased blood pressure;
- thrombosis.
Change in laboratory parameters:
- erythropenia;
- hyperprothrombinemia;
- thrombocytosis;
- hypokalemia;
- neutrophilic leukocytosis.
Other problems:
- increased body temperature;
- sodium retention;
- violation of the exchange of zinc and copper;
- hypovitaminosis;
- fluid retention in cells.

anemia;
renal failure;
hyperoxalaturia;
thalassemia;
hemochromatosis;
leukemia;
sideroblastic or sickle cell anemia;
malignant diseases;
lack of glucose-6-phosphate dehydrogenase.

Interaction with other drugs

During the period of taking ascorbic acid, the nuances of the interaction of the vitamin with other substances (drugs) should be taken into account. The following action is worth highlighting here:

Improving the absorption of iron in the intestine, as well as accelerating the removal of metal in the case of combination with Deferoxamine.
Increased risk of crystalluria during treatment with sulfonamides and sallicites. At the same time, the process of excretion of acids through the kidneys slows down, and the rate of withdrawal of drugs with an alkaline reaction also increases. In addition, the concentration of oral contraceptives in the blood decreases.
Depletion of vitamin C reserves in the case of taking salicylates, calcium chloride, and also the quinoline series.
Increasing the total ethanol clearance, which reduces the level of ascorbic acid in the blood and living tissues.
Decrease in absorption and deterioration in digestibility when combining vitamin C with acetylsalicylic acid, alkaline drinking, oral contraceptives.
An increase in the volume of tetracyclines and benzylpenicillin in the blood. Also, with an increase in dosage above one gram per day, the bioavailability of ethinylestradiol increases.
Increased renal excretion of mexiletine (in the case of taking ascorbic acid in high dosages).
Acceleration of the excretion of vitamin C in the urine in the case of taking Primidone and barbiturates.
Decrease in the chronotropic action of isoprenaline (with simultaneous administration).
Deterioration of the therapeutic effect of tricyclic antidepressants, tubular reabsorption of amphetamine, decrease in the effect of antipsychotics.

special instructions

For vitamin C, the instructions for the use of dragees stipulate a number of special instructions that should be followed during the course:

Reception of ascorbic acid is performed with caution in case of impaired renal function, hyperoxaluria, in the presence of indications of the presence of urolithiasis.
Because of the increased absorption of iron, high doses of vitamin C are dangerous for people with polycythemia, thalassemia, leukemia, and sideroblastic anemia. People with a high iron content in the body are advised to limit their intake of ascorbic acid.
In the case of increased intake, the condition may worsen in the presence of sickle cell anemia.
There is a high risk of exacerbation if the patient has disseminated or proliferating tumors, which can only aggravate the process.
It is recommended that diabetics keep their glucose levels under control while taking the drug.
With the use of vegetable or fruit juices, as well as alkaline drinks, vitamin C is absorbed and absorbed worse.
Due to the stimulatory effect of the substance on the production of corticosteroid hormones, it is recommended to monitor kidney function and periodically measure blood pressure.
During the period of taking ascorbic acid, the readings of many laboratory tests may be distorted.

Analogs

The pharmaceutical sector offers a wide range of preparations containing vitamin C. All of them differ in the amount of active substance, manufacturer, set of auxiliary elements and pricing policy. The most famous drugs include:

Tsevikap.
Celascone.
Multi-Tabs with Vitamin C.
Askovit.
Additive Vitamin C.
Setebe 500.
Plivit S.
Celaxon Effectscens.
Vitamin C PLUS Kid formula Farmamed and others.

Shelf life and storage conditions

Ascorbic acid in the form of pills has a shelf life of 1.5 years. The drug should be stored in a dark and dry place. Storage temperature - up to +25 degrees Celsius.

proteinfo.ru

Ascorbic acid dragee: instructions for use

Active ingredient: ascorbic acid;

1 tablet contains ascorbic acid - 50 mg;

auxiliary substances: starch syrup, white sugar, yellow wax, mineral oil, talc, orange flavor (contains propylene glycol).

Description

international non-proprietary name: ascorbic acid;

basic physical and chemical properties: white or white with a yellowish tinge dragee color. In appearance they should be spherical.

pharmachologic effect

Ascorbic acid (vitamin C) has pronounced reducing properties. Belongs to the group of water-soluble vitamins. Participates in redox reactions, regulation of carbohydrate metabolism, affects the exchange of aromatic amino acids, thyroxine metabolism, biosynthesis of catecholamines, steroid hormones and insulin, is necessary for blood coagulation, collagen and procollagen synthesis, regeneration of connective and bone tissue. Improves capillary penetration. Promotes the absorption of iron in the intestine and takes part in the synthesis of hemoglobin. Increases nonspecific resistance of the body, has antidote properties. Deficiency of vitamin C in food leads to the development of hypo- and avitaminosis C, since this vitamin is not synthesized in the body.

Absorption of ascorbic acid occurs mainly in the small intestine. The absorption process can be impaired with intestinal dyskinesias, enteritis, achilia, helminthic invasion, giardiasis, as well as when drinking alkaline drinks, fresh fruits and vegetable juices. The maximum concentration of the drug in plasma after oral administration is achieved after 4 hours. It easily penetrates into leukocytes, platelets, and then into all tissues; deposited in the posterior part of the pituitary gland, adrenal cortex, ocular epithelium, intermediate cells of the spermatic glands, ovaries, liver, brain, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland. It is metabolized mainly in the liver to deoxyascorbic acid and further to oxaloacetic and diketogulonic acids. Unchanged ascorbate and metabolites are excreted in urine, faeces and excreted in breast milk. When high doses are used, when the plasma concentration reaches more than 1.4 mg / dl, excretion is sharply increased, and increased excretion may persist after discontinuation of use.

Indications for use

Prevention and treatment of vitamin C deficiency in the body.

Prevention and treatment of scurvy, stimulation of tissue regeneration, in the complex therapy of bleeding (uterine, pulmonary, nasal), with radiation sickness syndrome, bone fractures, hemorrhagic diathesis, intoxications and infections, Addison's disease with an overdose of anticoagulants, during pregnancy and lactation, with increased mental stress and physical overload.

Contraindications

Hypersensitivity to ascorbic acid or to an auxiliary substance of the drug. Thrombosis, tendency to thrombosis, thrombophlebitis, diabetes mellitus, severe kidney disease. Urolithiasis - when using doses over 1 g per day. Fructose intolerance, glucose-galactose malabsorption syndrome.

Children under 4 years old.

Pregnancy and lactation

The lack of vitamin C in the diet of pregnant women can be dangerous for the fetus, however, its use in high doses can also negatively affect the development of the fetus, therefore, during pregnancy, ascorbic acid is used exclusively for the intended purpose and under the supervision of a physician, strictly adhering to the recommended doses (see section " Method of administration and dosage ").

Ascorbic acid penetrates into breast milk, therefore, during breastfeeding, vitamin C should be taken under the supervision of a physician, adhering to the recommended doses (see section "Dosage and Administration").

Method of administration and dosage

It is prescribed for adults and children over 4 years old. Dragee is taken orally after meals. The therapeutic dose for adults and children over 14 years of age is 50-100 mg (1-2 tablets) 3-5 times a day.

children aged 4-7 years - 50-100 mg (1-2 tablets), children aged 7-10 years - 100 mg (2 tablets),

children aged 11-14 years - 100-150 mg (2-3 tablets) 2-3 times a day.

For prophylactic purposes, ascorbic acid is prescribed for adults and children over the age of 14 in a daily dose of 50-100 mg (1-2 pills).

For the prevention of hypovitaminosis, children aged 4-14 years are prescribed 50 mg (1 tablet) 1 time per day.

Pregnant women, women after childbirth, as well as with a low level of vitamin C in breast milk are prescribed in a daily dose of 300 mg (6 tablets) for 10-15 days, after which (for prophylactic purposes throughout the entire period of breastfeeding) - in a daily dose 100 mg (2 tablets).

The duration of use is determined by the doctor depending on the nature of the pathological condition and the effectiveness of therapy.

Side effect

Ascorbic acid is generally well tolerated, but the following side reactions may occur:

on the part of the digestive tract: when used in a dose of more than 1 g per day - irritation of the mucous membrane of the digestive tract, heartburn, nausea, vomiting, diarrhea; from the urinary system: damage to the glomerular apparatus of the kidneys, crystalluria, the formation of urate, cystine and / or oxalate stones in the kidneys and urinary tract;

allergic reactions: skin rash, Quincke's edema, urticaria; sometimes - anaphylactic shock in the presence of sensitization;

on the part of the endocrine system: damage to the insular apparatus of the pancreas (hyperglycemia, glucosuria) and impaired glycogen synthesis up to the appearance of diabetes mellitus;

on the part of the cardiovascular system: arterial hypertension, myocardial dystrophy; from the side) 1y of the hematopoietic system: thrombocytosis, hyperprothrombinemia, erythrocytopenia, neutrophilic leukemia; in patients with deficiency of glucose-6-phosphate dehydrogenase of blood cells, hemolysis of erythrocytes can result;

from the nervous system: increased excitability, sleep disturbances, headache; from the side of metabolism: metabolic disorders of zinc, copper.

In case of any undesirable reactions, consult your doctor regarding the further use of the drug!

Overdose

Symptoms: with a single use of excessive doses of the drug, it is possible

the occurrence of nausea, vomiting, bloating and abdominal pain, itching, skin rash, hyperexcitability.

With prolonged use in high doses, it is possible to suppress the insular apparatus of the pancreas (it is necessary to control its function), the development of cystitis, the acceleration of the formation of calculi (urates, oxalates).

Treatment: drug withdrawal, gastric lavage, alkaline drink, intake of activated charcoal or other sorbents, symptomatic therapy.

Interaction with other medicinal products

If you are taking any other medications, be sure to inform your doctor!

The absorption of ascorbic acid is reduced with the simultaneous use of oral contraceptives, the use of fruit or vegetable juices, and alkaline drinks. Oral ascorbic acid increases the absorption of penicillin, tetracycline, iron, reduces the effectiveness of heparin and indirect anticoagulants, increases the risk of crystalluria during treatment with salicylates. The simultaneous intake of vitamin C and deferoxamine increases the tissue toxicity of iron, especially in the heart muscle, which can lead to decompensation of the circulatory system. Vitamin C can only be taken 2 hours after deferoxamine injection.

Long-term use of large doses by persons treated with disulfiramine inhibits the disulfiram-alcohol reaction. Large doses of the drug reduce the effectiveness of tricyclic antidepressants, neuroleptics - phenothiazine derivatives, tubular reabsorption of amphetamine, disrupt the excretion of mexiletine by the kidneys.

Ascorbic acid increases the total clearance of ethyl alcohol. Quinoline series drugs, calcium chloride, salicylates, corticosteroids, with prolonged use, reduce the reserves of ascorbic acid in the body.

Application features

The ability to influence the reaction rate when driving or operating other mechanisms. Does not affect.

Children. The drug is prescribed for children over 4 years old.

Precautions

Before starting treatment, consult your doctor!

When using the drug, you must adhere to the doses recommended by your doctor!

When taking high doses and long-term use of the drug, it is necessary to monitor renal function and blood pressure levels, as well as the function of the pancreas. It should be used with caution in patients with a history of kidney disease.

With urolithiasis, the daily dose of ascorbic acid should not exceed 1 g.

Do not prescribe large doses of the drug to patients with increased blood clotting.

Since Ascorbic Acid increases iron absorption, its use in high doses can be dangerous for patients with hemochromatosis, thalassemia, polycythemia, leukemia and sideroblastic anemia. Patients with a high iron content in the body need to use the drug in minimal doses.

Simultaneous reception with an alkaline drink reduces the absorption of ascorbic acid, so you should not drink pills with alkaline mineral water. Also, the absorption of ascorbic acid can be impaired in case of intestinal dyskinesia, enteritis and achilia. It is used with caution to treat patients with glucose-6-

phosphate dehydrogenase.

Ascorbic acid as a reducing agent can affect the results of laboratory studies, for example, in determining the blood glucose, bilirubin, transaminase activity, lactate dehydrogenase, etc.

Since Ascorbic Acid has a mild stimulating effect, it is not recommended to take the drug at the end of the day.

Release form

50 tablets with a dosage of 50 mg in containers. 1 container in a cardboard box.

Storage conditions

Store in original packaging at temperatures above 25 ° C.

Shelf life

1 year 6 months

Terms of dispensing from pharmacies

Without a doctor's prescription.

Ascorbic acid dragee analogs, synonyms and group preparations

Self-medication can be harmful to your health. You should consult your doctor and read the instructions before use.

Content

Since childhood, many parents have been given pills or tablets of vitamin C. This element is responsible for important biochemical and biological processes. Externally, the drug is a light-colored crystals with lemon flavor. However, not every person knows about all the properties of this substance.

How is ascorbic acid useful?

Many people take vitamin C without thinking about how it affects the human body. First of all, ascorbic acid is a very powerful antioxidant that helps to neutralize free oxygen atoms that harm the human body. Lack of vitamin C leads to a weakening of the immune system. Taking the drug in tablets, ampoules or powder strengthens the natural defenses of the human body of any age. The action of ascorbic acid includes neutralizing poisoning.

Why vitamin C is useful:

All collagen skin cosmetics contain this substance. Ascorbic acid stimulates the production of fibroblast cells, which contribute to the formation of epithelial and connective tissue.
It is very important to remember what vitamin C is for in the hematopoietic system. Without it, the correct exchange of folic acid and iron is impossible. Lack of this vitamin can cause anemia.
The use of ascorbic acid suppresses inflammatory reactions and reduces the risk of developing allergies.
Ascorbic acid can affect the production of steroid hormones and catecholamines, so it is important to use this substance for the normal functioning of the nervous, reproductive and endocrine systems.
Vitamin C strengthens blood vessels, accelerates blood clotting, and prevents the development of edema in women (during menstruation).
The use of tablets, ampoules, powder or dragees of this drug helps to overcome stress. In addition, this substance prevents the development of infectious diseases that attack the human body during stress, depression, weakened immunity.

Daily dose of ascorbic acid

Before starting to use the drug, it is recommended to find out the need of an adult and a child's body in this substance. How much ascorbic acid can you eat per day? Under normal conditions - no more than 50-100 mg. The dosage increases significantly (one-time - up to 1 g per day) if the body is exposed to high physical and mental stress, frequent exposure to low and high temperatures. In addition, the use of ascorbic acid in an increased volume requires:

women during pregnancy and breastfeeding;
athletes who are fond of bodybuilding;
patients during treatment.

How to take ascorbic acid

The patient may be prescribed, if indicated, intravenous or intramuscular injections, an effervescent solution from a powder or tablet. It is recommended to get individual instructions from your doctor on how to take ascorbic acid in order to avoid side effects. The dosage and form of administration depend on what function of the human body needs support.

How to take ascorbic acid in dragees correctly? The substance must be taken after meals in the following quantities:

Children - 25-75 mg (prevention), 50-100 mg three times daily (treatment).
Adults - 50-100 mg each (prophylaxis), during treatment, the indicated dose is increased to 200-400 mg, divided into several doses.
During pregnancy, you need to take 2 weeks at 300 mg, then reduce the dosage by three times.

Injections with glucose can be prescribed - 1-5 ml of sodium ascorbate solution up to three times daily. For the treatment of vitamin deficiency, children are prescribed powder in sachets of 0.05-0.1 g. It is important to follow the instructions. The doctor prescribes the course of treatment individually for each patient according to indications. The maximum daily volume of the substance is no more than 0.5 g (for an adult patient), for children - 30-50 mg (depending on the age of the child and the individual instructions for using the drug).

Ascorbic acid price

You can buy this drug inexpensively at any pharmacy, or order and buy in an online store. Manufacturers' catalogs contain many different options for vitamin C. As a rule, the price varies from 13 to 45 rubles. The cost is influenced by the brand of the manufacturer, the form of release. The price of ascorbic acid (dragee) in cans of 200 pieces (50 mg) does not differ much from different pharmaceutical companies. However, a significant runaway can be found when buying ascorbic acid tablets. Manufacturers are raising the price for bright packaging and flavorings.

How to choose ascorbic acid

Experts recommend getting your vitamin C from natural products. It can be contained in vegetables, herbs, fruits. With a strong lack of an element, you can buy ascorbic acid in powder. The most common form for prevention is dragee or chewable tablets. Injections, as a rule, are prescribed by a doctor for severe poisoning or for pregnant women to maintain the body.