Calcium gluconate tablets 500 mg. Appropriate safety precautions for use

03.11.2020

Release form

Tablets

Composition

1 tab. calcium gluconate monohydrate 500 mg. Excipients: potato starch 23 mg, talc 5 mg, calcium stearate monohydrate 2 mg.

Pharmacological effect

The calcium supplement compensates for the deficiency of calcium ions necessary for the transmission of nerve impulses, contraction of skeletal and smooth muscles, myocardial activity, bone formation, blood coagulation.

Pharmacokinetics

Approximately 1/5 to 1/3 of the orally administered drug is absorbed in the small intestine; this process depends on the presence of vitamin D, pH, diet and the presence of factors that can bind calcium ions. The absorption of calcium ions increases with its deficiency and the use of a diet with a reduced content of calcium ions. About 20% is excreted by the kidneys, the rest (80%) is removed with the intestinal contents.

Indications

Diseases accompanied by hypocalcemia, increased permeability of cell membranes (including vessels), impaired conduction of nerve impulses in muscle tissue. Hypoparathyroidism (latent tetany, osteoporosis), disorders of vitamin D metabolism: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure. Increased need for calcium ions (pregnancy, lactation period, period of increased body growth), insufficient content of calcium ions in food, impaired metabolism (in the postmenopausal period). Enhanced excretion of calcium ions (prolonged bed rest, chronic diarrhea, secondary hypocalcemia against the background of prolonged use of diuretics and antiepileptic drugs, glucocorticosteroids). Poisoning with salts of magnesium ions, oxalic and fluoric acids and their soluble salts (when interacting with calcium gluconate, insoluble and non-toxic calcium oxalate and calcium fluoride are formed). Hypercalcemic form of paroxysmal myoplegia.

Contraindications

Hypersensitivity, hypercalcemia (the concentration of calcium ions should not exceed 12 mg% ~ 6 mEq / l), severe hypercalciuria, nephrourolithiasis (calcium), sarcoidosis, simultaneous intake of cardiac glycosides (risk of arrhythmias), children under 3 years of age. Carefully. Dehydration, electrolyte disturbances (risk of hypercalcemia), diarrhea, malabsorption syndrome, mild hypercalciuria, moderate chronic renal failure, chronic heart failure, generalized atherosclerosis, hypercoagulation, calcium nephrourolithiasis (in history).

Application during pregnancy and lactation

Application is possible according to the dosage regimen.

Method of administration and dosage

Grind before use. Inside, before eating or 1-1.5 hours after ingestion (washed down with milk). Adults - 1-3 g 2-3 times a day (maximum daily dose - 9 g). Pregnant and lactating mothers - 1-3 g 2-3 times a day (maximum daily dose - 9 g). Children: 3-4 years old - 1 g (maximum daily dose - 3.0 g); 5-6 years old - 1-1.5 g (maximum daily dose - 4.5 g); 7-9 years old - 1.5-2 g (maximum daily dose - 6 g); 10-14 years old - 2-3 g (maximum daily dose - 9 g); frequency of admission - 2-3 times a day.

Side effects

Constipation, irritation of the gastrointestinal tract mucosa, hypercalcemia.

Overdose

Symptoms: development of hypercalcemia. Treatment: Calcitonin is administered 5-10 IU / kg / day. (diluting it in 500 ml of 0.9% sodium chloride solution). Duration of administration is 6 hours.

Interaction with other drugs

Forms insoluble complexes with tetracycline antibiotics (reduces the antibacterial effect). With simultaneous use with quinidine, it is possible to slow down intraventricular conduction and increase the toxicity of quinidine. Slows down the absorption of tetracyclines, digoxin, oral iron preparations (the interval between doses should be at least 2 hours). When combined with thiazide diuretics, it may increase hypercalcemia. Reduces the effect of calcitonin in hypercalcemia. Reduces the bioavailability of phenytoin.

special instructions

In patients with mild hypercalciuria, decreased glomerular filtration rate or a history of nephrourolithiasis, treatment should be carried out under the control of the concentration of calcium ions in the urine. Drinking plenty of fluids is recommended to reduce the risk of developing nephrourolithiasis.

In this article, you can read the instructions for using the drug Calcium gluconate... The reviews of website visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Calcium gluconate in their practice are presented. A big request is to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed that may not have been declared by the manufacturer in the annotation. Analogues of calcium gluconate in the presence of available structural analogs. Use for the treatment of osteoporosis and other forms of calcium deficiency in the body in adults, children, as well as during pregnancy and lactation.

Calcium gluconate - the calcium preparation compensates for the deficiency of calcium ions necessary for the transmission of nerve impulses, contraction of skeletal and smooth muscles, myocardial activity, the formation of bone tissue, blood coagulation.

Calcium - a macronutrient involved in the formation of bone tissue, the process of blood coagulation, is necessary to maintain stable cardiac activity, processes of transmission of nerve impulses. Improves muscle contraction in muscular dystrophy, myasthenia gravis, reduces vascular permeability. When administered intravenously, calcium causes excitement of the sympathetic nervous system and increased adrenal secretion of adrenaline; has a moderate diuretic effect.

Pharmacokinetics

Indications

diseases accompanied by hypocalcemia, increased permeability of cell membranes (including vessels), impaired conduction of nerve impulses in muscle tissue;
hypoparathyroidism (latent tetany, osteoporosis), disorders of vitamin D metabolism: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure;
increased need for calcium ions (pregnancy, lactation period, period of increased body growth), insufficient content of calcium ions in food, impaired metabolism (in the postmenopausal period);
increased excretion of calcium ions (prolonged bed rest, chronic diarrhea, secondary hypocalcemia against the background of long-term use of diuretics and antiepileptic drugs, glucocorticosteroids);
poisoning with salts of magnesium ions, oxalic and fluoric acids and their soluble salts (when interacting with calcium gluconate, insoluble and non-toxic calcium oxalate and calcium fluoride are formed);
hypercalcemic form of paroxysmal myoplegia.

Release forms

500 mg tablets

Chewable tablets 500 mg.

Solution for intravenous and intramuscular administration (injections for injection) in ampoules of 100 mg / ml.

Instructions for use and dosage

Grind before use.

Inside, before eating or 1-1.5 hours after ingestion (washed down with milk). Adults - 1-3 g 2-3 times a day (maximum daily dose - 9 g).

Pregnant and lactating mothers - 1-3 g 2-3 times a day (maximum daily dose - 9 g).

Children: 3-4 years old - 1 g (maximum daily dose - 3.0 g); 5-6 years old - 1-1.5 g (maximum daily dose - 4.5 g); 7-9 years old - 1.5-2 g (maximum daily dose - 6 g); 10-14 years old - 2-3 g (maximum daily dose - 9 g); frequency of admission - 2-3 times a day.

With intravenous or intramuscular administration of calcium gluconate solution, a single dose of the drug should correspond to 2.25-4.5 mmol of calcium. A solution of calcium chloride is injected intravenously in a stream (slowly) in a single dose of 500 mg, intravenously drip - in a single dose of 0.5-1 g.

Side effect

constipation;
irritation of the mucous membrane of the gastrointestinal tract;
hypercalcemia.

Contraindications

hypersensitivity;
hypercalcemia (the concentration of calcium ions should not exceed 12 mg%);
severe hypercalciuria;
nephrourolithiasis (calcium);
tendency to thrombosis;
sarcoidosis;
simultaneous intake of cardiac glycosides (risk of arrhythmias);
children under 3 years old.

Application during pregnancy and lactation

Application is possible according to the dosage regimen.

special instructions

In patients with mild hypercalciuria, decreased glomerular filtration rate, or a history of nephrourolithiasis, treatment should be carried out under the control of the concentration of calcium ions in the urine.

Drinking plenty of fluids is recommended to reduce the risk of developing nephrourolithiasis.

Calcium gluconate is similar in effect to calcium chloride, but is less irritating.

Drug interactions

Forms insoluble complexes with tetracycline antibiotics (reduces the antibacterial effect).

With simultaneous use with quinidine, it is possible to slow down intraventricular conduction and increase the toxicity of quinidine.

Slows down the absorption of tetracyclines, digoxin, oral iron preparations (the interval between their doses should be at least 2 hours).

When combined with thiazide diuretics, it may increase hypercalcemia. Reduces the effect of calcitonin in hypercalcemia. Reduces the bioavailability of phenytoin.

Analogues of the medicinal product Calcium gluconate

Structural analogues for the active substance:

Calcium gluconate B. Brown;
Calcium gluconate, stabilized;
Calcium gluconate-Vial;
Calcium gluconate-LekT;
Calcium gluconate solution for injection 10%.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.

Calcium gluconate is a medicine used to regulate calcium-phosphorus metabolism.

Pharmacological action of Calcium gluconate

The action of the drug Calcium gluconate is aimed at replenishing the Ca2 + deficiency, in which:

The process of transmission of nerve impulses worsens;
Contractions of smooth and skeletal muscles, bone formation, myocardial activity, blood coagulation are impaired.

Release form, composition and analogs of Calcium gluconate

Calcium gluconate containing the active substance of the same name is produced in the form:

500 mg chewable tablets;
Solution for injection in ampoules of 1, 2, 3, 5 and 10 ml;
Tablets of 250 and 500 mg.

According to the indications, the doctor may recommend one of the analogues of the medication with a similar effect. For example: Additive calcium, Hydroxyapatite, Glycerophosphate granules, Hydroxyapatite paste, CalViv, Calcium-Sandoz forte, Calcium lactate, Calcium lactate.

Indications for the use of Calcium gluconate

Calcium gluconate injections and tablet form of the drug are prescribed for the treatment of:

Hypoparathyroidism (latent tetany, osteoporosis);
Diseases accompanied by hypocalcemia, increased permeability of cell membranes, disorders in muscle tissue by the conduction of nerve impulses;
Enhanced excretion of Ca2 +, which occurs with prolonged adherence to bed rest, chronic diarrhea, secondary hypocalcemia against the background of prolonged use of diuretics, antiepileptic drugs, glucocorticosteroids;
Vitamin D metabolic disorders, including rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic kidney disease;
Hyperkalemic form of paroxysmal myoplegia;
Poisoning with Mg2 + salts, fluoric and oxalic acids, as well as their soluble salts.

Also, according to the instructions, Calcium gluconate is prescribed against the background of an increased need for Ca2 +, which occurs in children and adolescents during the period of intensive growth, with an unbalanced diet, in which Ca2 + deficiency occurs, as well as in the postmenopausal period with a violation of calcium-phosphorus metabolism.

For women, calcium gluconate is usually prescribed during pregnancy and during lactation because of the increased need for calcium during this period.

Contraindications

The medicine is not used against the background:

Hypercalcemia;
Hypersensitivity;
Nephrourolithiasis (calcium);
Severe hypercalciuria;
Simultaneous administration with cardiac glycosides (due to the risk of arrhythmias);
Sarcoidosis.

In pediatrics, medication in any dosage form is approved for use from the age of three.

When using Calcium gluconate, care must be taken when:

Electrolyte disturbances (due to an increased risk of developing hypercalcemia);
Dehydration;
Malabsorption syndrome;
Diarrhea;
Minor hypercalciuria;
Calcium nephrourolithiasis (in history);
Chronic heart failure;
Moderate chronic renal failure;
Hypercoagulation;
Common atherosclerosis.

Method of application of Calcium gluconate

Calcium gluconate tablets are taken before meals or 1-1.5 hours after meals. It is recommended to drink the medicine with milk. The adult daily dosage varies from 2 to 9 g, depending on the indications, for children, from 1 g, depending on age. The frequency of use of tablets is 2-3 times a day.

Injections of Calcium gluconate with a 10% solution of room temperature are given intramuscularly, intravenously slowly (2-3 minutes) or drip. The medication, depending on the indications, is administered daily or every other day.

To reduce the risk of developing nephrourolithiasis during therapy, it is recommended to drink plenty of fluids.

Dosages for the use of Calcium gluconate during pregnancy and lactation should be checked with the attending physician.

Side effects

When taking Calcium gluconate tablets, constipation and irritation of the mucous membrane of the gastrointestinal tract may occur.

When administered intramuscularly or intravenously, Calcium gluconate, according to reviews, can lead to the development of:

Nausea;
Vomiting;
Diarrhea;
Bradycardia;
Burning sensation in the mouth;
Feeling hot;
Reducing blood pressure;
Arrhythmias;
Fainting;
Cardiac arrest;
Necrosis at the injection site.

When using higher dosages, Calcium gluconate, according to reviews, can cause hypercalcemia, for the treatment of which parenteral calcitonin is used.

Drug interactions Calcium gluconate

During therapy, it should be borne in mind that Calcium gluconate, according to the instructions, is pharmaceutically incompatible with salicylates, carbonates and sulfates.

You should also know that Calcium gluconate at the same time:

Tetracycline antibiotics forms insoluble complexes, which reduces the antibacterial effect;
BMCC leads to a decrease in its effect;
Quinidine can slow down intraventricular conduction and cause an increase in its toxicity;
Fe slows down their absorption with tetracyclines, digoxin, oral medications. The interval between the use of drugs should be at least two hours;
Thiazide diuretics enhances hypercalcemia;
Calcitonin reduces its effect when used against the background of hypercalcemia;
Phenytoin reduces its bioavailability.

Storage conditions

Calcium gluconate is one of the regulators of calcium-phosphorus metabolism, dispensed from pharmacies only by prescription. The shelf life of tablets is 5 years, chewable tablets - 24 months, solution for injection - 2.5 years, provided that the medicine is stored in accordance with the manufacturer's recommendations.

Composition and form of release

Tablets - 1 tab .: calcium gluconate 500 mg.

10 pieces. - non-cell contoured packaging (3) - cardboard packs.

Description of the dosage form

Tablets are white, flat-cylindrical, chamfered and scored.

pharmachologic effect

Calcium - a macronutrient involved in the formation of bone tissue, the process of blood coagulation, is necessary to maintain stable cardiac activity, processes of transmission of nerve impulses. Improves muscle contraction in muscular dystrophy, myasthenia gravis, reduces vascular permeability. When administered intravenously, calcium causes excitation of the sympathetic nervous system and increased adrenaline secretion by the adrenal glands; has a moderate diuretic effect.

Pharmacokinetics

Clinical pharmacology

A drug that replenishes calcium deficiency in the body.

Indications for use

Diseases accompanied by hypocalcemia, increased permeability of cell membranes (including vessels), impaired conduction of nerve impulses in muscle tissue.

Hypoparathyroidism (latent tetany, osteoporosis), disorders of vitamin D metabolism: rickets (spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure.

Increased need for calcium ions (pregnancy, lactation period, period of increased body growth), insufficient content of calcium ions in food, impaired metabolism (in the postmenopausal period).

Enhanced excretion of calcium ions (prolonged bed rest, chronic diarrhea, secondary hypocalcemia against the background of prolonged use of diuretics and antiepileptic drugs, glucocorticosteroids).

Poisoning with salts of magnesium ions, oxalic and fluoric acids and their soluble salts (when interacting with calcium gluconate, insoluble and non-toxic calcium oxalate and calcium fluoride are formed).

Hypercalcemic form of paroxysmal myoplegia.

Contraindications for use

Carefully. Dehydration, electrolyte disturbances (risk of hypercalcemia), diarrhea, malabsorption syndrome, mild hypercalciuria, moderate chronic renal failure, chronic heart failure, widespread atherosclerosis, hypercoagulation, calcium nephrourolithiasis (in history).

Use during pregnancy and children

Application is possible according to the dosage regimen.

Application in children

Contraindicated in children under 3 years of age.

Side effects

Constipation, irritation of the gastrointestinal tract mucosa, hypercalcemia.

Drug interactions

Calcium gluconate, when used simultaneously, reduces the effect of calcium channel blockers. Intravenous administration of calcium gluconate before or after verapamil reduces its hypotensive effect, but does not affect its antiarrhythmic effect. Under the influence of cholestyramine, the absorption of calcium from the gastrointestinal tract is reduced. With simultaneous use with quinidine, it is possible to slow down intraventricular conduction and increase the toxicity of quinidine. During treatment with cardiac glycosides, parenteral administration of calcium gluconate is not recommended due to increased cardiotoxicity. With the simultaneous oral administration of calcium gluconate and tetracyclines, the effect of the latter may decrease, due to a decrease in their absorption.

Dosage

For oral administration, a single dose is 1-3 g, the frequency of administration is 2-3 times / day. With intravenous or intramuscular injection of calcium gluconate solution, a single dose of the drug should correspond to 2.25-4.5 mmol of calcium. A solution of calcium chloride is injected intravenously in a stream (slowly) in a single dose of 500 mg, intravenously drip - in a single dose of 0.5-1 g.

Overdose

Symptoms: development of hypercalcemia.

Treatment: Calcitonin is administered 5-10 IU / kg / day. (diluting it in 500 ml of 0.9% sodium chloride solution). Duration of administration is 6 hours.

Precautions

To reduce the risk of developing nephrourolithiasis, it is recommended to drink plenty of fluids.

active substance:calcium gluconate;

1 tablet contains calcium gluconate 500 mg;

excipients:potato starch, talc, calcium stearate.

Dosage form. Tablets.

Basic physical and chemical properties:one-piece, regular, round cylinders, the upper and lower surfaces of which are flat, the edges of the surfaces are beveled, with a dividing line, white. Marbling is allowed on the surface of the tablets.

Pharmacotherapeutic group.

Mineral supplements. Calcium preparations. ATX code А12А А03.

Pharmacological properties

Pharmacodynamics.

Calcium gluconate is a calcium salt of gluconic acid containing 9% calcium. Calcium ions are involved in the transmission of nerve impulses, contraction of smooth and skeletal muscles, the functioning of the myocardium, blood coagulation processes; they are necessary for the formation of bone tissue, the normal functioning of other systems and organs. The concentration of calcium ions in the blood decreases in many pathological processes; severe hypocalcemia contributes to the onset of tetany. Calcium gluconate, in addition to eliminating hypocalcemia, reduces vascular permeability, has antiallergic, anti-inflammatory, hemostatic effect, and also reduces exudation. Calcium ions are a plastic material for the skeleton and teeth, participate in various enzymatic processes, regulate the speed of nerve impulses and the permeability of cell membranes. Calcium ions are necessary for the process of neuromuscular transmission, to maintain the contractile function of the myocardium. Unlike calcium chloride, calcium gluconate has a weaker local irritant effect.

Pharmacokinetics.

When taken orally, calcium gluconate is partially absorbed mainly in the small intestine. The maximum concentration in blood plasma is reached in 1.2-1.3 hours. The half-life of ionized calcium from blood plasma is 6.8-7.2 hours. Penetrates through the placental barrier and is excreted in breast milk. It is excreted from the body in urine and feces.

Clinical characteristics.

Indications.

Diseases accompanied by hypocalcemia, increased permeability of cell membranes, impaired conduction of nerve impulses in muscle tissue. Hypoparathyroidism (latent tetany, osteoporosis), impaired vitamin D metabolism (rickets, spasmophilia, osteomalacia), hyperphosphatemia in patients with chronic renal failure.

Increased need for calcium (period of intensive growth of children and adolescents, pregnancy or lactation), insufficient Ca 2+ content in food, impaired metabolism in the postmenopausal period, bone fractures. Increased excretion of Ca 2+ (prolonged bed rest, chronic diarrhea, hypocalcemia with prolonged use of diuretics, antiepileptic drugs, glucocorticosteroids). In complex therapy: bleeding of different etiology, allergic diseases (serum sickness, urticaria, febrile syndrome, itchy dermatoses, angioedema); bronchial asthma, dystrophic alimentary edema, pulmonary tuberculosis, eclampsia, parenchymal hepatitis, liver toxicity, nephritis. As an antidote for poisoning with magnesium salts, oxalic acid, soluble salts of fluoric acid (when interacting with calcium gluconate, insoluble and non-toxic calcium oxalate and calcium fluoride are formed).

Contraindications

Hypersensitivity to drug components. Hypercalcemia, severe hypercalciuria, hypercoagulability, a tendency to thrombosis, severe atherosclerosis, increased blood coagulation, nephrourolithiasis (calcium), severe renal failure, sarcoidosis, digitalis drugs.

Interaction with other medicinal products and other types of interactions.

The drug slows down the absorption of estramustine, etidronate and other bisphosphonates, quinolones, tetracycline antibiotics, oral iron and fluoride preparations (the interval between doses should be at least 3 hours). Calcium gluconate reduces the bioavailability of phenytoin. When taken simultaneously with vitamin D or its derivatives, calcium absorption increases. Cholesterolamine reduces the absorption of calcium in the digestive tract. When the drug is used together with cardiac glycosides, the cardiotoxic effects of the latter are enhanced. Glucocorticosteroids decrease calcium absorption. When combined with thiazide diuretics, the risk of developing hypercalcemia may increase. The drug can reduce the effect of calcitonin in hypercalcemia, the bioavailability of phenytoin, the effect of calcium channel blockers. With simultaneous use with quinidine, it is possible to slow down intraventricular conduction and increase the toxicity of quinidine.

Forms insoluble or slightly soluble calcium salts with carbonates, salicylates, sulfates.

Absorption of calcium from the digestive tract can reduce certain types of food (spinach, rhubarb, bran, grains).

Application features

When used in patients receiving cardiac glycosides and / or diuretics, as well as with long-term treatment, it is necessary to control the concentration of calcium and creatinine in the blood. In case of an increase in their concentration, it is necessary to reduce the dose of the drug or temporarily stop its use. Due to the fact that vitamin D 3 increases the absorption of calcium from the digestive tract, in order to avoid an overdose of calcium, it is necessary to take into account the intake of vitamin D 3 and calcium from other sources.

With caution and with regular monitoring of the level of urinary calcium excretion, it is prescribed to patients with moderate hypercalciuria exceeding 300 mg / day (7.5 mmol / day), mild renal dysfunction, a history of urolithiasis. If necessary, you need to reduce the dose of the drug or cancel it. Patients with a tendency to form calculi in the urinary tract are advised to increase the amount of fluid consumed during treatment.

When treating with the drug, you should avoid taking high doses of vitamin D or its derivatives, unless there are special indications for this.

It is necessary to adhere to an interval of at least 3 hours between taking Calcium gluconate and preparations for oral administration of estramustine, etidronate and other bisphosphonates, phenytoin, quinolones, tetracycline antibiotics, oral iron preparations and fluoride preparations.

Application during pregnancy or lactation.

The use of the drug is permissible taking into account the ratio of benefit to the woman / risk to the fetus / child, which is determined by the doctor.

When taking calcium supplements during lactation, its penetration into breast milk is possible.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

Does not affect.

Method of administration and dosage

Assign orally, before meals. The tablet must be chewed or crushed.

For adults and children from 14 years of age, the drug should be prescribed in a single dose of 1-3 g (2-6 tablets), for children from 3 to 4 years old - 1 g each (2 tablets), from 5 to 6 years old - 1-1.5 g each (2-3 tablets), from 7 to 9 years old - 1.5-2 g each (3-4 tablets), from 10 to 14 years old - 2-3 g each (4-6 tablets) 2-3 times a day ...

The daily dose for elderly patients should not exceed 2 g (4 tablets).

The duration of treatment is determined by the doctor individually, depending on the patient's condition.

Children.

The drug should be used in children from 3 years of age.

Overdose

With prolonged use in high doses, hypercalcemia with the deposition of calcium salts in the body is possible, dyspeptic symptoms are possible. The likelihood of developing hypercalcemia increases with simultaneous treatment with high doses of vitamin D or its derivatives.

Hypercalcemia symptoms:drowsiness, weakness, anorexia, abdominal pain, vomiting, nausea, constipation, polydipsia, polyuria, weakness, increased fatigue, irritability, feeling unwell, depression, dehydration, heart rhythm disturbances, myalgia, arthralgia, arterial hypertension are possible.

Treatment:drug withdrawal; in severe cases - parenteral calcitonin at a dose of 5-10 IU / kg of body weight per day (diluting it in 500 ml of 0.9% sodium chloride solution), intravenously drip for 6 hours. Possibly intravenous jet slow injection 2-4 times a day.

Adverse reactions

Usually the drug is well tolerated, but sometimes allergic reactions and other disorders are possible:

from the digestive tract: nausea, vomiting, diarrhea, abdominal pain, constipation; with prolonged use in high doses - the formation of calcium calculi in the intestine;

on the part of the cardiovascular system: bradycardia;

from the side of metabolism: hypercalcemia, hypercalciuria;

from the urinary system:impaired renal function (increased urination, edema of the lower extremities).

These phenomena disappear quickly after dose reduction or drug withdrawal.

Shelf life

Storage conditions

Store in its original packaging at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Packaging

10 tablets in blisters.

Manufacturer.

JSC "Lubnyfarm".

Manufacturer's location and address of the place of business.

Ukraine, 37500, Poltava region, Lubny, st. Barvinkova, 16.